Journal article
Advances in inclusion body myositis: genetics, pathogenesis and clinical aspects
Expert Opinion on Orphan Drugs, Vol.5(5), pp.431-443
04/2017
Abstract
Introduction: Inclusion body myositis is the most common acquired muscle disease affecting older adults. It has an insidious onset with a very specific pattern of muscle involvement, but the aetiopathogenesis is still unknown. Pathologically the combination of inflammatory changes, degenerative changes as well as mitochondrial and nuclear changes are seen, and probably all contribute to the loss of muscle, however the primary abnormality remains a mystery. Treatment is currently supportive, but clinical trials are ongoing and are directed at new targets.
Areas covered: Clinical profile, genetic susceptibility, pathogenesis and treatment
Expert opinion: Understanding the aetiopathogeneis is vital to identify future treatment targets. In addition, understanding the natural history and the roles of biomarkers including the anti-CN1a antibody is vital for designing future clinical trials in IBM, to be properly designed and of sufficient duration to detect clinically significant changes.
Details
- Title
- Advances in inclusion body myositis: genetics, pathogenesis and clinical aspects
- Authors/Creators
- M. Needham (Author/Creator)F.L. Mastaglia (Author/Creator)
- Publication Details
- Expert Opinion on Orphan Drugs, Vol.5(5), pp.431-443
- Publisher
- Taylor & Francis
- Identifiers
- 991005544093307891
- Copyright
- © 2017 Informa UK Limited
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology