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Journal article
Adverse Events Following Vaccines: From Detection to Research Translation
Annual review of public health, Vol.46(1), pp.1-19
2025
PMID: 39656965
Abstract
Vaccines are lifesaving interventions that reduce the morbidity and mortality of disease. Fortunately, serious adverse events with vaccination are uncommon, but they must promptly be recognized and evaluated to assess and clarify the safety of future administration, a process that the public must understand in order to feel safe in receiving vaccines. In this article, we provide a review of vaccine development, discuss the process by which safety is ensured, and describe key adverse events associated with their administration. We review in detail existing mechanisms for reporting these events and assessing them following recovery, as well as communication related to vaccine safety. We also describe barriers to vaccination, such as nocebo effects and antivaccination groups, and use lessons learned from the successful development of COVID-19 vaccines during the recent pandemic to define future opportunities and directions for vaccine safety.
Details
- Title
- Adverse Events Following Vaccines: From Detection to Research Translation
- Authors/Creators
- Edward Fernandez - Vanderbilt University Medical CenterJordon Jaggers - Massachusetts General HospitalAllison E Norton - Monroe Carell Jr. Children's HospitalCosby Stone - Vanderbilt University Medical CenterElizabeth Phillips - Vanderbilt University Medical Center
- Publication Details
- Annual review of public health, Vol.46(1), pp.1-19
- Publisher
- Annual Reviews
- Number of pages
- 19
- Grant note
- US Centers from Disease Control and PreventionAgency for Healthcare Research and Quality: R01HS03023401 National Institute of Allergy and Infectious Diseases: U01AI181927 Vanderbilt-Ingram Cancer Center/Chic Awearness P3 Pilot AwardJanssenServierUS National Institutes of Health: R01HG010863, R01AI152183, U01AI154659 Australian National Health and Medical Research CouncilEsperion
DISCLOSURE STATEMENT A.E.N. receives salary support from the US Centers from Disease Control and Prevention as a subject matter expert for drug and vaccine reactions in the CISA (Clinical Immunization Safety Assessment) division. C.S. receives funding from the Agency for Healthcare Research and Quality (grant R01HS03023401) , the National Institute of Allergy and Infectious Diseases (grant U01AI181927) , and a Vanderbilt-Ingram Cancer Center/Chic Awearness P3 Pilot Award, which is unrelated to this review. E.P. is the drug allergy section editor of and reviews content for UpToDate and Lexicomp. She has received funding from Janssen, Verve, Rapt, Servier, and Esperion. She receives grant funding as a principal investigator from the US National Institutes of Health (grants R01HG010863, R01AI152183, and U01AI154659) and the Australian National Health and Medical Research Council. The other authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this review.
- Identifiers
- 991005765129407891
- Copyright
- © 2025 by the author(s).
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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