Journal article
Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys
Journal of Gastroenterology and Hepatology, Vol.31(5), pp.980-987
2016
Abstract
Background and Aims:
Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) share risk associations of adiposity and insulin resistance. We examined the impact of a PCOS diagnosis on the metabolic phenotype of adolescent girls with NAFLD and compared this to girls without PCOS or NAFLD and to age-matched boys.
Methods:
Community-based adolescents from the Raine Cohort participated in assessments for NAFLD (572 girls and 592 boys) and PCOS (244 girls). One hundred and ninety-nine girls attended both assessments.
Results:
Amongst the 199 girls, PCOS was diagnosed in 16.1% and NAFLD in 18.6%. NAFLD was diagnosed in 10.1% of the boys. NAFLD was more prevalent in girls with PCOS than girls without PCOS (37.5% vs 15.1%, P = 0.003). Girls with NAFLD plus PCOS had greater adiposity (waist circumference, body mass index, suprailiac skinfold thickness [SST], serum androgens, high-sensitivity C-reactive protein, ferritin, homeostasis model assessment for insulin resistance (HOMA-IR), and lower serum sex hormone binding globulin levels than girls with NAFLD without a PCOS diagnosis (all P < 0.05). Girls with NAFLD plus PCOS had similar adiposity, HOMA-IR, and adiponectin levels to boys with NAFLD, but more adiposity, serum leptin and HOMA-IR than both girls and boys without NAFLD. PCOS (odds ratios 2.99, 95% confidence intervals 1.01–8.82, P = 0.048) and SST (odds ratios 1.14, 95% confidence intervals 1.08–1.20, P < 0.001) independently predicted NAFLD in adolescent girls, however, serum androgens and HOMA-IR levels did not.
Conclusions:
Adolescent girls with NAFLD plus PCOS have a similar metabolic phenotype to boys with NAFLD. Increasing SST and pre-existing PCOS independently predict NAFLD in adolescent girls.
Details
- Title
- Adverse metabolic phenotype of adolescent girls with non-alcoholic fatty liver disease plus polycystic ovary syndrome compared with other girls and boys
- Authors/Creators
- O.T. Ayonrinde (Author/Creator) - The University of Western AustraliaL.A. Adams (Author/Creator) - The University of Western AustraliaD.A. Doherty (Author/Creator) - The University of Western AustraliaT.A. Mori (Author/Creator) - The University of Western AustraliaL.J. Beilin (Author/Creator) - The University of Western AustraliaW.H. Oddy (Author/Creator) - The Kids Research Institute AustraliaM. Hickey (Author/Creator) - The University of MelbourneD.M. Sloboda (Author/Creator) - McMaster UniversityJ.K. Olynyk (Author/Creator) - Fiona Stanley HospitalR. Hart (Author/Creator) - The University of Western Australia
- Publication Details
- Journal of Gastroenterology and Hepatology, Vol.31(5), pp.980-987
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005545106507891
- Copyright
- © 2015 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.663 NAFLD
- Web Of Science research areas
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- Clinical Medicine