Journal article
Aerobic exercise, cardiorespiratory fitness, and the human hippocampus
Hippocampus, Vol.31(8), pp.817-844
2021
Abstract
The hippocampus is particularly susceptible to neurodegeneration. Physical activity, specifically increasing cardiorespiratory fitness via aerobic exercise, shows promise as a potential method for mitigating hippocampal decline in humans. Numerous studies have now investigated associations between the structure and function of the hippocampus and engagement in physical activity. Still, there remains continued debate and confusion about the relationship between physical activity and the human hippocampus. In this review, we describe the current state of the physical activity and exercise literature as it pertains to the structure and function of the human hippocampus, focusing on four magnetic resonance imaging measures: volume, diffusion tensor imaging, resting-state functional connectivity, and perfusion. We conclude that, despite significant heterogeneity in study methods, populations of interest, and scope, there are consistent positive findings, suggesting a promising role for physical activity in promoting hippocampal structure and function throughout the lifespan.
Details
- Title
- Aerobic exercise, cardiorespiratory fitness, and the human hippocampus
- Authors/Creators
- S.L. Aghjayan (Author/Creator) - University of PittsburghA. Lesnovskaya (Author/Creator) - University of PittsburghI. Esteban‐Cornejo (Author/Creator)J.C. Peven (Author/Creator) - University of PittsburghC.M. Stillman (Author/Creator) - University of PittsburghK.I. Erickson (Author/Creator) - University of Pittsburgh
- Publication Details
- Hippocampus, Vol.31(8), pp.817-844
- Publisher
- Wiley
- Identifiers
- 991005542098807891
- Copyright
- © 2021 Wiley Periodicals LLC
- Murdoch Affiliation
- College of Science, Health, Engineering and Education
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior