Journal article
Aeromonas allosaccharophila Strain AE59-TE2 Is Highly Antagonistic towards Multidrug-Resistant Human Pathogens, What Does Its Genome Tell Us?
Life (Basel, Switzerland), Vol.12(10), 1492
2022
PMID: 36294926
Abstract
Multidrug-resistant bacteria are of critical importance and a problem for human health and food preservation; the discovery of new antimicrobial substances to control their proliferation is part of the solution. This work reports on 57 antagonistic Aeromonas strains, of which 38 strains were antagonistic towards problematic human pathogens. The genome of the most antagonistic strain was sequenced and identified as Aeromonas allosaccharophila. Its genome was fully annotated and mined for genes that might explain that activity. Strain AE59-TE was antagonistic toward clinically relevant gram-negative and gram-positive multidrug-resistant bacteria, including Klebsiella pneumoniae KPC, Escherichia coli ESBL, Salmonella typhimurium, and Staphylococcus aureus MRSA. Strain AE59-TE2 was identified by multilocus sequence analysis. Genome mining identified four genes homologous to the bacteriocin, zoocin A from Streptococcus equi and a gene 98% similar to cvpA linked to colicin V production. A. allosaccharophila strain AE59-TE2 produced antimicrobial activity against a broad range of bacteria, including important gram-negative bacteria, not typically targeted by bacteriocins. Herewere described novel zoocin genes that are promising for industrial applications in the food and health sectors. Interesting and important antagonistic activity is described combined with the first detailed genomic analysis of the species Aeromonas allosaccharophila.
Details
- Title
- Aeromonas allosaccharophila Strain AE59-TE2 Is Highly Antagonistic towards Multidrug-Resistant Human Pathogens, What Does Its Genome Tell Us?
- Authors/Creators
- Sheila da Silva - Programa Pós-Graduação de Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilFernanda Alves de Freitas Guedes - Programa Pós-Graduação de Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilJoão Ricardo Vidal Amaral - Programa Pós-Graduação de Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilJosé Roberto de Assis Ribeiro - Programa Pós-Graduação de Biotecnologia Vegetal e Bioprocessos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilYuri Pinheiro Alves de Souza - Helmholtz Zentrum Munchen COMI, Research Unit Comparative Microbiome Analysis, GermanyÂngela Correa de Freitas-Almeida - Departamento de Microbiologia, Imunologia e Parasitologia, Centro Biomédico, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, BrazilFabiano Lopes Thompson - Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilRommel Thiago Jucá Ramos - Instituto de Ciências Biológicas, Centro de Genômica e Biologia de Sistemas, Universidade Federal do Pará (UFPA), Belém, BrazilAndrew Steven Whiteley - ACTAndrew Macrae - Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, BrazilSelma Soares de Oliveira - Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
- Publication Details
- Life (Basel, Switzerland), Vol.12(10), 1492
- Grant note
- 141225/2018-1 / Conselho Nacional de Desenvolvimento Científico e Tecnológico (http://data.elsevier.com/vocabulary/SciValFunders/501100003593) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (http://data.elsevier.com/vocabulary/SciValFunders/501100002322) Coordination for the Qualification of Higher Level Staff Conselho Nacional de Desenvolvimento Científico e Tecnológico (http://data.elsevier.com/vocabulary/SciValFunders/501100003593)
- Identifiers
- 991005894366507891
- Copyright
- © 2022 by the authors.
- Murdoch Affiliation
- Food Futures Institute
- Language
- English
- Resource Type
- Journal article
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