Age at onset in two common neurodegenerative diseases is genetically controlled

Y-J Li; W.K. Scott; D.J. Hedges; F. Zhang; P.C. Gaskell; M.A. Nance; R.L. Watts; J.P. Hubble; W.C. Koller; R. Pahwa; M.B. Stern; B.C. Hiner; J. Jankovic; F.H. Allen; C.G. Goetz; F. Mastaglia; J.M. Stajich; R.A. Gibson; L.T. Middleton; A.M. Saunders; B.L. Scott; G.W. Small; K.K. Nicodemus; A.D. Reed; D.E. Schmechel; K.A. Welsh-Bohmer; P.M. Conneally; A.D. Roses; J.R. Gilbert; J.M. Vance; J.L. Haines; M.A. Pericak-Vance

doi:10.1086/339815

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Age at onset in two common neurodegenerative diseases is genetically controlled

Journal article

Peer reviewed

Age at onset in two common neurodegenerative diseases is genetically controlled

Y-J Li, W.K. Scott, D.J. Hedges, F. Zhang, P.C. Gaskell, M.A. Nance, R.L. Watts, J.P. Hubble, W.C. Koller, R. Pahwa, …

The American Journal of Human Genetics, Vol.70(4), pp.985-993

2002

DOI: https://doi.org/10.1086/339815

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Abstract

To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%–60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.

Details

Title: Age at onset in two common neurodegenerative diseases is genetically controlled
Authors/Creators: Y-J Li (Author/Creator)
W.K. Scott (Author/Creator)
D.J. Hedges (Author/Creator)
F. Zhang (Author/Creator)
P.C. Gaskell (Author/Creator)
M.A. Nance (Author/Creator)
R.L. Watts (Author/Creator)
J.P. Hubble (Author/Creator)
W.C. Koller (Author/Creator)
R. Pahwa (Author/Creator)
M.B. Stern (Author/Creator)
B.C. Hiner (Author/Creator)
J. Jankovic (Author/Creator)
F.H. Allen (Author/Creator)
C.G. Goetz (Author/Creator)
F. Mastaglia (Author/Creator)
J.M. Stajich (Author/Creator)
R.A. Gibson (Author/Creator)
L.T. Middleton (Author/Creator)
A.M. Saunders (Author/Creator)
B.L. Scott (Author/Creator)
G.W. Small (Author/Creator)
K.K. Nicodemus (Author/Creator)
A.D. Reed (Author/Creator)
D.E. Schmechel (Author/Creator)
K.A. Welsh-Bohmer (Author/Creator)
P.M. Conneally (Author/Creator)
A.D. Roses (Author/Creator)
J.R. Gilbert (Author/Creator)
J.M. Vance (Author/Creator)
J.L. Haines (Author/Creator)
M.A. Pericak-Vance (Author/Creator)
Publication Details: The American Journal of Human Genetics, Vol.70(4), pp.985-993
Publisher: Cell Press
Identifiers: 991005543949607891
Copyright: © 2002 The American Society of Human Genetics
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Industry collaboration; Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Mechanisms
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics