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Journal article
Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection
Frontiers in aging neuroscience, Vol.16, 1432357
2025
PMID: 39839305
Abstract
Cognitive changes associated with PASC may not be uniform across populations. We conducted individual-level pooled analyses and meta-analyses of cognitive assessments from eight prospective cohorts, comprising 2,105 patients and 1,432 controls from Argentina, Canada, Chile, Greece, India, Italy, Russia, and the UK. The meta-analysis found no differences by country of origin. The profile and severity of cognitive impairment varied by age, with mild attentional impairment observed in young and middle-aged adults, but memory, language, and executive function impairment in older adults. The risk of moderate to severe impairment doubled in older adults. Moderately severe or severe impairment was significantly associated with infection diagnoses (chi-square = 26.57,
p
≤ 0.0001) and the severity of anosmia (chi-square = 31.81,
p
≤ 0.0001). We found distinct age-related phenotypes of cognitive impairment in patients recovering from COVID-19. We identified the severity of acute illness and the presence of olfactory dysfunction as the primary predictors of dementia-like impairment in older adults.
Details
- Title
- Age-dependent phenotypes of cognitive impairment as sequelae of SARS-CoV-2 infection
- Authors/Creators
- Gabriela Gonzalez Aleman - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,George D. Vavougios - University of ThessalyCarmela Tartaglia - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Nalakath A. Uvais - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Alla Guekht - Pirogov Russian National Research Medical UniversityAkram A. Hosseini - Nottingham University Hospitals NHS TrustVincenzina Lo Re - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Catterina Ferreccio - Pontificia Universidad Católica de ChileGiovanni D'Avossa - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Hernan P. Zamponi - National University of JujuyMariana Figueredo Aguiar - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Agustin Yecora - Fundación para la Lucha contra las Enfermedades Neurológicas de la InfanciaMohammad Zia Ul Haq Katshu - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Vasileios T. Stavrou - University of CyprusStylianos Boutlas - University of CyprusKonstantinos I. Gourgoulianis - University of CyprusCamila Botero - Pontificia Universidad Católica ArgentinaFrancisco González Insúa - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Santiago Perez-Lloret - Pontificia Universidad Católica ArgentinaMikhail Zinchuk - Moscow Research and Clinical Center for NeuropsychiatryAnna Gersamija - Moscow Research and Clinical Center for NeuropsychiatrySofya Popova - Moscow Research and Clinical Center for NeuropsychiatryYulia Bryzgalova - Moscow Research and Clinical Center for NeuropsychiatryEkaterina Sviatskaya - Moscow Research and Clinical Center for NeuropsychiatryGiovanna Russelli - Istituto Mediterraneo per i Trapianti e Terapie ad Alta SpecializzazioneFederica Avorio - University of PalermoSophia Wang - Indiana University – Purdue University IndianapolisPaul Edison - Cardiff UniversityYoshiki Niimi - The University of TokyoHamid R. Sohrabi - Murdoch University, Centre for Healthy AgeingElizabeta B. Mukaetova Ladinska - , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,Daria Neidre - Institute for Neurodegenerative DisordersGabriel A. de Erausquin - The University of Texas Health Science Center at San Antonio
- Publication Details
- Frontiers in aging neuroscience, Vol.16, 1432357
- Publisher
- Frontiers Media S.A.
- Number of pages
- 11
- Grant note
- Fundacion FULTRA, ArgentinaNational Institute of Aging: U19AG076581, P30AG059305, P30AG066546, 23245 EU-OSHAUniversity Hospital FoundationIQRAA International Hospital and Research Center, Calicut, Kerala, IndiaItalian Health Ministry, Ricerca CorrenteANID/CONICYT FONDECYT: 1212066, ANID/FONDAP/15130011 NIA: K23AG06255, NIA R21AG074179, NIA P30AG072976 NIAJPND/Italian Ministry/(European Union) Medical Research Council and National Institute for Health Research, UKJPND/Italian Ministry/(European Union) Medical Research Council and National Institute for Health Research, UKWestern Australia Department of Jobs, TourismWestern Australia Department of Jobs, Tourism
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors were funded completely of partially by: Fundacion FULTRA, Argentina (GG, HZ, AY, MF), National Institute of Aging Grants # U19AG076581, P30AG059305, and P30AG066546 (GE), ISIDORe (PID: 23245) (GV), COVALENT study, included herein received funding from EU-OSHA (SB, KG), University Hospital Foundation (CT), IQRAA International Hospital and Research Center, Calicut, Kerala, India (NU, MU), Italian Health Ministry, Ricerca Corrente 2023 (VL, GR, FA), ANID/CONICYT FONDECYT Regular 1212066; ANID/FONDAP/15130011 (CF), NIA K23AG06255, NIA R21AG074179, NIA P30AG072976 (SW), JPND/Italian Ministry/(European Union) Medical Research Council and National Institute for Health Research, UK (PE), Western Australia Department of Jobs, Tourism, Science and Innovation grant for the Effect of COVID-19 on mental health of the elderly (HS). In addition, GV, KG, and VS would like to thank the personnel of the COVID-19 outpatient clinic and as well as research collaborators on long COVID research: Nico Biagi, Dimitrios Mysiris, Kyriaki Astara, Eleana Pitaraki, Konstantinos Tourlakopoulos, Eirini Papayianni, Glykeria Tsirimona, & Iacute;lias E. Dimeas, Pelagia Foka, Olga Papaggeli, Georgia Xiromerisiou, Sotirios Zarogiannis, Zoe Daniil 2, and Georgios Hadjigeorgiou.
- Identifiers
- 991005732476307891
- Copyright
- © 2025 Gonzalez Aleman et al.
- Murdoch Affiliation
- Centre for Healthy Ageing; School of Psychology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.104 Virology - General
- 1.104.1353 Coronavirus Research
- Web Of Science research areas
- Geriatrics & Gerontology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior