Journal article
Age-related differences in corticospinal excitability during a Go/NoGo task
Psychophysiology, Vol.48(10), pp.1448-1455
2011
Abstract
Age-related slowing of reaction times (RTs) is well documented but whether the phenomenon reflects deficits in movement preparation and/or response generation processes is unclear. To gain further insight into this issue, transcranial magnetic stimulation (TMS) was used to investigate motor cortex (M1) excitability and short-interval intracortical inhibitory (SICI) processes during a Go/NoGo RT task in younger and older adults. Single- and paired-pulse TMS was delivered over the left M1 during preparation and response generation periods in a right-hand muscle. Younger adults had shorter RTs and a larger increase in corticospinal excitability at response generation period than older adults. SICI modulation for both groups showed a large reduction in inhibition immediately prior to EMG onset. These findings indicate age-related differences in corticospinal excitability during the response generation stage of sensorimotor information processing.
Details
- Title
- Age-related differences in corticospinal excitability during a Go/NoGo task
- Authors/Creators
- H. Fujiyama (Author/Creator) - University of TasmaniaC. Tandonnet (Author/Creator) - University of TasmaniaJ.J. Summers (Author/Creator) - University of Tasmania
- Publication Details
- Psychophysiology, Vol.48(10), pp.1448-1455
- Publisher
- Wiley
- Identifiers
- 991005542170207891
- Copyright
- © 2011 Society for Psychophysiological Research
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Neurosciences
- Physiology
- Psychology
- Psychology, Biological
- Psychology, Experimental
- ESI research areas
- Psychiatry/Psychology