Journal article
Aggregation of abnormal memory scores and risk of incident Alzheimer’s disease dementia: A measure of objective memory impairment in amnestic mild cognitive impairment
Journal of the International Neuropsychological Society, Vol.27(2), pp.146-157
2021
Abstract
Objectives:
The criteria for objective memory impairment in mild cognitive impairment (MCI) are vaguely defined. Aggregating the number of abnormal memory scores (NAMS) is one way to operationalise memory impairment, which we hypothesised would predict progression to Alzheimer’s disease (AD) dementia.
Methods:
As part of the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing, 896 older adults who did not have dementia were administered a psychometric battery including three neuropsychological tests of memory, yielding 10 indices of memory. We calculated the number of memory scores corresponding to z ≤ −1.5 (i.e., NAMS) for each participant. Incident diagnosis of AD dementia was established by consensus of an expert panel after 3 years.
Results:
Of the 722 (80.6%) participants who were followed up, 54 (7.5%) developed AD dementia. There was a strong correlation between NAMS and probability of developing AD dementia (r = .91, p = .0003). Each abnormal memory score conferred an additional 9.8% risk of progressing to AD dementia. The area under the receiver operating characteristic curve for NAMS was 0.87 [95% confidence interval (CI) .81–.93, p < .01]. The odds ratio for NAMS was 1.67 (95% CI 1.40–2.01, p < .01) after correcting for age, sex, education, estimated intelligence quotient, subjective memory complaint, Mini-Mental State Exam (MMSE) score and apolipoprotein E ϵ4 status.
Conclusions:
Aggregation of abnormal memory scores may be a useful way of operationalising objective memory impairment, predicting incident AD dementia and providing prognostic stratification for individuals with MCI.
Details
- Title
- Aggregation of abnormal memory scores and risk of incident Alzheimer’s disease dementia: A measure of objective memory impairment in amnestic mild cognitive impairment
- Authors/Creators
- N.I. Bradfield (Author/Creator) - St Vincent's HealthK.A. Ellis (Author/Creator) - The University of MelbourneG. Savage (Author/Creator) - Macquarie UniversityP. Maruff (Author/Creator) - Cogstate Pty Ltd, Melbourne, Victoria, Australia.S. Burnham (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationD. Darby (Author/Creator) - Florey Institute of Neuroscience and Mental HealthN.T. Lautenschlager (Author/Creator) - The University of MelbourneR.N. Martins (Author/Creator) - Edith Cowan UniversityC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthS.R. Rainey-Smith (Author/Creator)J. Robertson (Author/Creator) - Florey Institute of Neuroscience and Mental HealthC. Rowe (Author/Creator) - Austin HospitalM. Woodward (Author/Creator) - Heidelberg Repatriation HospitalD. Ames (Author/Creator) - Florey Institute of Neuroscience and Mental Health
- Publication Details
- Journal of the International Neuropsychological Society, Vol.27(2), pp.146-157
- Publisher
- Cambridge University Press
- Identifiers
- 991005543749107891
- Copyright
- © 2020 INS
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Psychiatry
- Psychology
- ESI research areas
- Neuroscience & Behavior