Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

N.J. Armstrong; K.A. Mather; A. Thalamuthu; M.J. Wright; J.N. Trollor; D. Ames; H. Brodaty; P.R. Schofield; P.S. Sachdev; J.B. Kwok

doi:10.2217/epi-2016-0179

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Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

Journal article

Peer reviewed

Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks

N.J. Armstrong, K.A. Mather, A. Thalamuthu, M.J. Wright, J.N. Trollor, D. Ames, H. Brodaty, P.R. Schofield, P.S. Sachdev and J.B. Kwok

Epigenomics, Vol.9(5), pp.689-700

2017

DOI: https://doi.org/10.2217/epi-2016-0179

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Abstract

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.

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Title: Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks
Authors/Creators: N.J. Armstrong (Author/Creator) - UNSW Sydney
K.A. Mather (Author/Creator) - UNSW Sydney
A. Thalamuthu (Author/Creator) - UNSW Sydney
M.J. Wright (Author/Creator) - The University of Queensland
J.N. Trollor (Author/Creator) - UNSW Sydney
D. Ames (Author/Creator) - The University of Melbourne
H. Brodaty (Author/Creator) - UNSW Sydney
P.R. Schofield (Author/Creator) - Neuroscience Research Australia
P.S. Sachdev (Author/Creator) - UNSW Sydney
J.B. Kwok (Author/Creator) - UNSW Sydney
Publication Details: Epigenomics, Vol.9(5), pp.689-700
Publisher: Future Medicine Ltd
Identifiers: 991005544746207891
Copyright: © 2017 Future Medicine Ltd
Murdoch Affiliation: School of Mathematical and Physical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.100 Epigenetic Regulation
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics