Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract

P.A. Stumbles; J.W. Upham; P.G. Holt

doi:10.1034/j.1600-0463.2003.11107806.x

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Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract

Journal article

Peer reviewed

Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract

P.A. Stumbles, J.W. Upham and P.G. Holt

APMIS, Vol.111(7-8), pp.741-755

2003

DOI: https://doi.org/10.1034/j.1600-0463.2003.11107806.x

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Abstract

The large quantities and complex mixtures of antigens encountered daily at airway mucosal and alveolar surfaces pose a major challenge to maintenance of immunological homeostasis in the respiratory tract. Amongst this myriad of antigens, the immune system must discriminate between innocuous components that can be tolerated by the host and potentially life-threatening pathogens that require a rapid immune response. Dendritic cells (DC) represent the principal cell type at these sites capable of processing antigens and delivering signals that initiate tolerogenic or immunogenic immune responses. This review will discuss the role of DC at the “front-line” of immune surveillance and homeostasis within the respiratory tract and their role in the pathogenesis of respiratory disease.

Details

Title: Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract
Authors/Creators: P.A. Stumbles (Author/Creator) - The Kids Research Institute Australia
J.W. Upham (Author/Creator) - The Kids Research Institute Australia
P.G. Holt (Author/Creator) - The Kids Research Institute Australia
Publication Details: APMIS, Vol.111(7-8), pp.741-755
Publisher: Wiley-Blackwell
Identifiers: 991005542846307891
Copyright: 2003 APMIS
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.358 Dendritic Cell Therapy
Web Of Science research areas: Immunology; Microbiology; Pathology
ESI research areas: Molecular Biology & Genetics