Alginate Oligosaccharides repair liver injury by improving Anti-Inflammatory capacity in a Busulfan-Induced Mouse Model

Yanan Hao; Hanhan Fang; Xiaowei Yan; Wei Shen; Jing Liu; Pengfei Han; Yong Zhao; Weidong Zhang; Yanni Feng

doi:10.3390/ijms24043097

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Alginate Oligosaccharides repair liver injury by improving Anti-Inflammatory capacity in a Busulfan-Induced Mouse Model

Journal article

Open access

Peer reviewed

Alginate Oligosaccharides repair liver injury by improving Anti-Inflammatory capacity in a Busulfan-Induced Mouse Model

Yanan Hao, Hanhan Fang, Xiaowei Yan, Wei Shen, Jing Liu, Pengfei Han, Yong Zhao, Weidong Zhang and Yanni Feng

International journal of molecular sciences, Vol.24(4), 3097

2023

DOI: https://doi.org/10.3390/ijms24043097

PMID: 36834506

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Abstract

Alginates - pharmacology

Animals

Anti-Inflammatory Agents

Busulfan

Disease Models, Animal

Liver

Mice

Oligosaccharides - pharmacology

Liver diseases are associated with many factors, including medicines and alcoholics, which have become a global problem. It is crucial to overcome this problem. Liver diseases always come with inflammatory complications, which might be a potential target to deal with this issue. Alginate oligosaccharides (AOS) have been demonstrated to have many beneficial effects, especially anti-inflammation. In this study, 40 mg/kg body weight (BW) of busulfan was intraperitoneally injected once, and then the mice were dosed with ddH O or AOS 10 mg/kg BW every day by oral gavage for five weeks. We investigated AOS as a potential no-side-effect and low-cost therapy for liver diseases. For the first time, we discovered that AOS 10 mg/kg recovered liver injury by decreasing the inflammation-related factors. Moreover, AOS 10 mg/kg could improve the blood metabolites related to immune and anti-tumor effects, and thus, ameliorated impaired liver function. The results indicate that AOS may be a potential therapy to deal with liver damage, especially in inflammatory conditions.

Details

Title: Alginate Oligosaccharides repair liver injury by improving Anti-Inflammatory capacity in a Busulfan-Induced Mouse Model
Authors/Creators: Yanan Hao - Qingdao Agricultural University
Hanhan Fang - Qingdao Agricultural University
Xiaowei Yan - Qingdao Agricultural University
Wei Shen - Qingdao Agricultural University
Jing Liu - Qingdao Agricultural University
Pengfei Han - Qingdao Agricultural University
Yong Zhao - State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Weidong Zhang - Institute of Animal Sciences
Yanni Feng - Qingdao Agricultural University
Publication Details: International journal of molecular sciences, Vol.24(4), 3097
Publisher: MDPI
Grant note: ZR2021MC111 / National Natural Science Foundation of China
Identifiers: 991005599563907891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.180 Microbial Biotechnology; 3.180.2418 Sugar Isomerization
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
ESI research areas: Chemistry