Journal article
Alleles of the IL12B 3′UTR associate with late onset of type 1 diabetes
Human Immunology, Vol.65(12), pp.1432-1436
2004
Abstract
Carriage of a polymorphism in the 3′untranslated region of the IL12B gene encoding IL-12p40 was investigated in subjects with type 1 diabetes mellitus stratified by age at diagnosis (n = 648) and compared with a population-based control cohort (n = 246) residing in Western Australia. DNA samples were genotyped by polymerase chain reaction-restriction fragment length polymorphism or pyrosequencing. The C allele was more common in patients diagnosed after age 16 years than in controls (29% vs 17%, OR = 2.0, 95% CI = 1.4-2.7, p = 0.00003) or than in patients diagnosed when younger age 16 years (29% vs 22%, OR = 1.4, 95% CI = 1.1-1.9, p = 0.01). This reflected increases in homozygous and heterozygous carriage of the C allele. Heterozygosity was associated with a delayed disease in the late-onset diabetics (p = 0.005; Student's t-test). The effects of IL12B 3′untranslated region alleles on type 1 diabetes mellitus may reflect different levels of p40 available to form p40 homodimer, IL-12 (p35p40), and IL-23 (p19p40).
Details
- Title
- Alleles of the IL12B 3′UTR associate with late onset of type 1 diabetes
- Authors/Creators
- L. Windsor (Author/Creator) - The University of Western AustraliaG. Morahan (Author/Creator) - UWA Centre for Medical ResearchD. Huang (Author/Creator) - Walter and Eliza Hall Institute of Medical ResearchV. McCann (Author/Creator) - Royal Perth HospitalT. Jones (Author/Creator) - The Kids Research Institute AustraliaI. James (Author/Creator) - Murdoch UniversityF.T. Christiansen (Author/Creator) - Royal Perth HospitalP. Price (Author/Creator) - Royal Perth Hospital
- Publication Details
- Human Immunology, Vol.65(12), pp.1432-1436
- Publisher
- Elsevier BV
- Identifiers
- 991005540496407891
- Copyright
- © American Society for Histocompatibility and Immunogenetics, 2004
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.26 Diabetes
- 1.26.1016 Type 1 Diabetes
- Web Of Science research areas
- Immunology
- ESI research areas
- Immunology