Journal article
Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and IgM memory B cells
Biology of Blood and Marrow Transplantation, Vol.15(7), pp.795-803
2009
Abstract
Allogeneic hematopoietic stem cell transplant (HSCT) recipients were assessed to elucidate memory B cell defects underlying their increased susceptibility to infections, particularly by encapsulated bacteria. Circulating IgM memory B cells (CD19+, CD27+, IgM+) and switched memory B cells (CD19+, CD27+, IgM-) were enumerated in allogeneic HSCT recipients (n = 37) and healthy controls (n = 35). T lymphocyte subpopulations and serum levels of immunoglobulins, including IgG subclasses, and antibodies to pneumococcal polysaccharides were also assayed. Allogeneic HSCT recipients were deficient in both switched memory and IgM memory B cells compared to healthy controls (both P < .0001), irrespective of time post-HSCT. Switched memory B cell deficiency correlated with CD4+ T cell deficiency, and both correlated with serum levels of IgG1 (P < .0001), possibly reflecting impaired B cell isotype switching in germinal centres. "Steady-state" serum levels of antibodies to pneumococcal polysaccharides did not correlate with circulating memory B cells. Graft-versus-host disease (GVHD) was associated with lower IgM memory B cell counts and lower serum levels of IgG2, IgG4, IgA, and pneumococcal antibodies. The increased susceptibility of allogeneic HSCT patients to infection may reflect a combination of memory B cell defects, which are most common in patients with a history of GVHD.
Details
- Title
- Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and IgM memory B cells
- Authors/Creators
- L.J. D'Orsogna (Author/Creator)M.P. Wright (Author/Creator)R.G. Krueger (Author/Creator)E.J. McKinnon (Author/Creator)S.I. Buffery (Author/Creator)C.S. Witt (Author/Creator)N. Staples (Author/Creator)R. Loh (Author/Creator)P.K. Cannell (Author/Creator)F.T. Christiansen (Author/Creator)M.A. French (Author/Creator)
- Publication Details
- Biology of Blood and Marrow Transplantation, Vol.15(7), pp.795-803
- Publisher
- Elsevier BV
- Identifiers
- 991005544986107891
- Copyright
- © 2009 American Society for Blood and Marrow Transplantation.
- Murdoch Affiliation
- Centre for Clinical Immunology and Biomedical Statistics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.103 Blood Disorders
- 1.103.380 GvHD
- Web Of Science research areas
- Hematology
- Immunology
- Transplantation
- ESI research areas
- Immunology