Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis

R.F.L. Steuart; R.M. O'Handley; R.J. Lipscombe; R.A. Lock; R.C.A. Thompson

doi:10.1017/S0031182008004988

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Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis

Journal article

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Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis

R.F.L. Steuart, R.M. O'Handley, R.J. Lipscombe, R.A. Lock and R.C.A. Thompson

Parasitology, Vol.135(14), pp.1621-1627

2008

DOI: https://doi.org/10.1017/S0031182008004988

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Abstract

Giardia

comparative proteomics

inter-assemblage variation

alpha 2 giardin

Of the 7 genetic assemblages of the parasite Giardia duodenalis only 2 (A and B) are known to cause infections in humans. These assemblages have been characterized in detail at the genomic level but few studies have examined differences in the proteins expressed. Employing one and two-dimensional PAGE we have identified an assemblage A-specific protein of human infective G. duodenalis; alpha 2 giardin. The protein difference was evident using both electrophoretic techniques. Alpha 2 giardin is known to be a structural protein and associates with the caudal flagella and the plasma membrane; however, its exact function is unknown. Although several proteins unique to assemblage B were also observed, we were unable to identify these proteins due to a lack of genomic data available for assemblage B isolates. Together, these proteins represent distinct phenotypic differences between the human infective assemblages of G. duodenalis and support the need to revise the taxonomy of this parasite.

Details

Title: Alpha 2 giardin is an assemblage A-specific protein of human infective Giardia duodenalis
Authors/Creators: R.F.L. Steuart (Author/Creator)
R.M. O'Handley (Author/Creator)
R.J. Lipscombe (Author/Creator)
R.A. Lock (Author/Creator)
R.C.A. Thompson (Author/Creator)
Publication Details: Parasitology, Vol.135(14), pp.1621-1627
Publisher: Cambridge University Press
Number of pages: 7
Identifiers: 991005541214207891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.246 Diarrheal Diseases; 1.246.985 Cryptosporidium
Web Of Science research areas: Parasitology
ESI research areas: Microbiology