Journal article
Alterations in opioid system of the rat brain after cat odor exposure
Neuroscience Letters, Vol.377(2), pp.136-139
2005
Abstract
The effect of cat odor exposure was studied on morphine-induced increase of exploratory behavior and on the expression of opioid genes in forebrain structures of male Wistar rats. Treatment with morphine (1 mg/kg) induced a significant increase in exploratory behavior in an unfamiliar environment in rats. Previous exposure of animals to cat odor completely abolished this stimulating action of μ-opioid receptor agonist on exploratory activity. Cat odor exposure induced a significant increase in the expression of pro-opio-melanocortin (POMC) and μ-opioid receptor (MOR) genes in the brain structures related to anxiety and motivation. This study clearly demonstrates that cat odor exposure increases the activity of opioid system in rat forebrain structures.
Details
- Title
- Alterations in opioid system of the rat brain after cat odor exposure
- Authors/Creators
- T. Areda (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuM-A Philips (Author/Creator) - University of TartuE. Vasar (Author/Creator) - University of TartuA. Karis (Author/Creator) - University of TartuT. Asser (Author/Creator) - University of Tartu
- Publication Details
- Neuroscience Letters, Vol.377(2), pp.136-139
- Publisher
- Elsevier
- Identifiers
- 991005543633207891
- Copyright
- © 2004 Elsevier Ireland Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.1090 Fear Conditioning
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior