Journal article
Alterations in phage-typing patterns in vancomycin-intermediate Staphylococcus aureus
Journal of Medical Microbiology, Vol.52(8), pp.711-714
2003
Abstract
The ability of phage-typing and Smal chromosomal RFLPs to conclude appropriate strain relatedness between a collection of 12 well-characterized in vitro-selected vancomycin-intermediate Staphylococcus aureus (VISA) strains and their seven vancomycin-susceptible parent strains is reported. Generally, no Smal RFLP alterations were observed in VISA strains when they were compared with their respective parent strains, and clonal relationships between isogenic strains were clearly evident. Unlike the Smal RFLP results, parent strains and VISA derivatives generally did not share similar phage-typing profiles. Depending on the phage set investigated, some VISA strains even became untypable by this method. Loss of phage infectivity is probably due to cell wall (phage receptor) alterations that are expressed by the VISA strains investigated. Collectively, these findings indicate that inappropriate relationships between VISA and vancomycin-susceptible parents might be drawn if only phage-typing and antibiotic susceptibility are utilized to determine epidemiological relationships.
Details
- Title
- Alterations in phage-typing patterns in vancomycin-intermediate Staphylococcus aureus
- Authors/Creators
- J.E. Gustafson (Author/Creator) - New Mexico State UniversityF.G. O'Brien (Author/Creator) - New Mexico State UniversityG.W. Coombs (Author/Creator) - New Mexico State UniversityM.J. Malkowski (Author/Creator) - New Mexico State UniversityW.B. Grubb (Author/Creator) - New Mexico State UniversityR.F. Pfeltz (Author/Creator) - New Mexico State UniversityB.J. Wilkinson (Author/Creator) - New Mexico State University
- Publication Details
- Journal of Medical Microbiology, Vol.52(8), pp.711-714
- Publisher
- Society for General Microbiology
- Identifiers
- 991005545061707891
- Copyright
- © 2003 SGM
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.173 MRSA and VRE
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology