Alterations in systemic and local colonic hemodynamic variables associated with intravenous infusion of ATP-MgCl2 in healthy anesthetized horses

Joanne Tetens; Susan C. Eades; Giselle Hosgood; Catherine E. Koch; Rustin M. Moore

doi:10.2460/ajvr.2001.62.1240

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Alterations in systemic and local colonic hemodynamic variables associated with intravenous infusion of ATP-MgCl2 in healthy anesthetized horses

Journal article

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Alterations in systemic and local colonic hemodynamic variables associated with intravenous infusion of ATP-MgCl2 in healthy anesthetized horses

Joanne Tetens, Susan C. Eades, Giselle Hosgood, Catherine E. Koch and Rustin M. Moore

American journal of veterinary research, Vol.62(8), pp.1240-1249

2001

DOI: https://doi.org/10.2460/ajvr.2001.62.1240

PMID: 11497445

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Abstract

Objective To characterize alterations in systemic and local colonic hemodynamic variables associated with IV infusion of ATP-MgCl2 in healthy anesthetized horses. Animals 12 adult horses. Procedure Six horses were given ATP-MgCl2, IV, beginning at a rate of 0.1 mg of ATP/kg of body weight/min with incremental increases until a rate of 1.0 mg/kg/min was achieved. The remaining 6 horses were given an equivalent volume of saline (0.9% NaCl) solution over the same time period. Colonic and systemic hemodynamic variables and colonic plasma nitric oxide (NO) concentrations were determined before, during, and after infusion. Results Infusion of ATP-MgCl2 caused a rate-dependent decrease in systemic and colonic vascular resistance, principally via its vasodilatory effects. A rate of 0.3 mg of ATP/kg/min caused a significant decrease in systemic and colonic arterial pressure and colonic vascular resistance without a significant corresponding decrease in colonic arterial blood flow. Consistent alterations in NO concentrations of plasma obtained from colonic vasculature were not detected, despite profound vasodilatation of the colonic arterial vasculature. Conclusions and Clinical Relevance Results revealed that IV infusion of ATP-MgCl2 may be beneficial in maintaining colonic perfusion in horses with ischemia of the gastrointestinal tract, provided a sufficient pressure gradient exists to maintain blood flow.

Details

Title: Alterations in systemic and local colonic hemodynamic variables associated with intravenous infusion of ATP-MgCl2 in healthy anesthetized horses
Authors/Creators: Joanne Tetens
Susan C. Eades
Giselle Hosgood
Catherine E. Koch
Rustin M. Moore
Publication Details: American journal of veterinary research, Vol.62(8), pp.1240-1249
Identifiers: 991005591575407891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.232 Veterinary Sciences; 3.232.1936 Equine and Bovine Gastrointestinal Disorders
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science