Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: Clues to the development of multiple sclerosis

A.P. Jones; S. Trend; S.N. Byrne; M.J. Fabis-Pedrini; S. Geldenhuys; D. Nolan; D.R. Booth; W.M. Carroll; R.M. Lucas; A.G. Kermode; P.H. Hart

doi:10.1038/cti.2017.18

$Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: Clues to the development of multiple sclerosis$

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Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: Clues to the development of multiple sclerosis

A.P. Jones, S. Trend, S.N. Byrne, M.J. Fabis-Pedrini, S. Geldenhuys, D. Nolan, D.R. Booth, W.M. Carroll, R.M. Lucas, A.G. Kermode, …

Clinical & Translational Immunology, Vol.6(5)

2017

DOI: https://doi.org/10.1038/cti.2017.18

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Abstract

Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment-naive individuals with recently diagnosed CIS (<120 days) for disturbances in the phenotype of T regulatory (Treg), follicular T regulatory (Tfr), T helper (Th), follicular T helper (Tfh) and B cells. Relative to healthy controls (n=19), CIS was associated with lower proportions of suppressive CD45RA+FoxP3lo Treg and Tfr cells and greater proportions of non-suppressive CD45RA−FoxP3lo and Th17-like Treg and Tfr. Lower Helios expression (maen fluorescent intensity) was measured across all Treg and Tfr fractions in the CIS group, suggesting less potent regulatory function. Greater frequencies of activated, efficient B-cell helper Tfh subsets and a trend for a higher proportion of IgD−CD27− B cells was also detected in the CIS group, characteristics that were positively correlated with Treg and Tfr Helios expression. These results indicate that Treg and Tfr impairment is an early feature in MS.

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Title: Altered regulatory T-cell fractions and Helios expression in clinically isolated syndrome: Clues to the development of multiple sclerosis
Authors/Creators: A.P. Jones (Author/Creator) - The Kids Research Institute Australia
S. Trend (Author/Creator) - The Kids Research Institute Australia
S.N. Byrne (Author/Creator) - The University of Sydney
M.J. Fabis-Pedrini (Author/Creator) - Sir Charles Gairdner Hospital
S. Geldenhuys (Author/Creator) - The Kids Research Institute Australia
D. Nolan (Author/Creator) - Murdoch University
D.R. Booth (Author/Creator) - Westmead Institute for Medical Research
W.M. Carroll (Author/Creator) - Sir Charles Gairdner Hospital
R.M. Lucas (Author/Creator) - Australian National University
A.G. Kermode (Author/Creator) - Sir Charles Gairdner Hospital
P.H. Hart (Author/Creator) - The Kids Research Institute Australia
Publication Details: Clinical & Translational Immunology, Vol.6(5)
Publisher: Australasian Society for Immunology Inc.
Identifiers: 991005540359207891
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.6 Immunology; 1.6.487 Regulatory T Cells
Web Of Science research areas: Immunology
ESI research areas: Immunology