Journal article
Alternative splicing of leptin receptor overlapping transcript in osteosarcoma
Experimental Biology and Medicine
2020
Abstract
Alternative splicing of RNA is an essential mechanism that increases proteomic diversity in eukaryotic cells. Aberrant alternative splicing is often associated with various human diseases, including cancer. We conducted whole-transcriptome analysis of 18 osteosarcoma bone samples (paired normal—tumor biopsies). Using RNA-seq, we identified statistically significant (FDR <0.05) 26 differentially expressed transcript variants of leptin receptor overlapping transcript (LEPROT) gene. Some of the transcripts were overexpressed in normal cells, whereas others were overexpressed in tumor cells. The function of LEPROT is not completely understood. Herein, we highlight a possible association between OS and aberrant alternative splicing events and its interaction with the expression of LEPROT. We also discuss the role of LEPROT in regulating growth hormone and its receptor, and the relationship with initiation and progression of OS. This research study may help to understand the association of alternative splicing mechanism in OS and in tumorigenesis more generally. Further, LEPROT gene can also be considered as a potential biomarker of osteosarcoma.
Details
- Title
- Alternative splicing of leptin receptor overlapping transcript in osteosarcoma
- Authors/Creators
- E. Rothzerg (Author/Creator) - The University of Western AustraliaX.D. Ho (Author/Creator) - Hue UniversityJ. Xu (Author/Creator) - The University of Western AustraliaD. Wood (Author/Creator) - The University of Western AustraliaA. Märtson (Author/Creator) - Tartu University HospitalK. Maasalu (Author/Creator) - Tartu University HospitalS. Kõks (Author/Creator) - Perron Institute for Neurological and Translational Science
- Publication Details
- Experimental Biology and Medicine
- Publisher
- SAGE Publications
- Identifiers
- 991005541971007891
- Copyright
- © 2020 by The Society for Experimental Biology and Medicine
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.54 Molecular & Cell Biology - Genetics
- 1.54.469 Alternative Splicing
- Web Of Science research areas
- Medicine, Research & Experimental
- ESI research areas
- Clinical Medicine