Journal article
Alu polymorphism within the MICB gene and association with HLA-B alleles
Immunogenetics, Vol.53(10-11), pp.975-979
2002
Abstract
We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0 (absence of insertion) and AluyMICB*1 (presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.113-0.118) but was strongly associated with HLA-B17 (HLA-B57, HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci.
Details
- Title
- Alu polymorphism within the MICB gene and association with HLA-B alleles
- Authors/Creators
- J.K. Kulski (Author/Creator)D.S. Dunn (Author/Creator)J. Hui (Author/Creator)P. Martinez (Author/Creator)A.V. Romphruk (Author/Creator)C. Leelayuwat (Author/Creator)G.K. Tay (Author/Creator)A. Oka (Author/Creator)H. Inoko (Author/Creator)
- Publication Details
- Immunogenetics, Vol.53(10-11), pp.975-979
- Publisher
- Springer-Verlag
- Identifiers
- 991005542763807891
- Murdoch Affiliation
- Centre for Comparative Genomics; School of Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.607 MHC Diversity
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Immunology