Journal article
Alzheimer's disease and the early signs of age-related macular degeneration
Current Alzheimer Research, Vol.13(11), pp.1259-1266
2016
Abstract
This study investigated signs of age related macular degeneration (AMD) in Alzheimer’s disease (AD). These age-related diseases primarily affect different parts of the central nervous system but are substantially similar in terms of abnormal extracellular deposits, metabolic and oxidative stress, neuroinflammation and microvascular abnormalities. While AMD is a retinal disease, AD is reported to affect not only the brain but also the retina, with Aβ deposits, neurodegeneration and vascular changes. Large population based studies have provided conflicting results regarding the comorbidity of AD and AMD.
This study investigated signs of AMD in a small but well characterized cohort from the Australian Imaging Biomarkers and Lifestyle study of aging (AIBL). The cohort consisted of 22 AD patients (age 70.2 ± 9.0 yrs, 13 male, 9 female) and 101 cognitively normal (CN) participants (age 71.3 ± 6.0 yrs, 40 male, 61 female).
In comparison with the CN group, the AD group had a greater proportion of participants with early AMD (p < 0.0001, odds ratio 18.67, 95% CI 4.42 – 78.80). A logistic model for early AMD found a significant association with AD diagnosis (p < 0.0001), after adjusting for confounders (age, smoking, hypertension, high and low density lipoproteins, cataract surgery and APOE ε4 carrier status).
The results of this study are consistent with an increased risk of AMD in AD. While the pathophysiology of these diseases are unclear, understanding the shared features between them may provide further knowledge about their pathogenesis and could lead to accelerated development of therapies for both diseases.
Details
- Title
- Alzheimer's disease and the early signs of age-related macular degeneration
- Authors/Creators
- S. Frost (Author/Creator) - Commonwealth Scientific and Industrial Research OrganisationR. Guymer (Author/Creator) - The University of MelbourneK.Z. Aung (Author/Creator) - The University of MelbourneS.L. Macaulay (Author/Creator) - CSIRO ManufacturingH.R. Sohrabi (Author/Creator) - Edith Cowan UniversityP. Bourgeat (Author/Creator) - CSIRO Health and BiosecurityO. Salvado (Author/Creator) - CSIRO Health and BiosecurityC.C. Rowe (Author/Creator) - Austin HealthD. Ames (Author/Creator) - National Ageing Research InstituteC.L. Masters (Author/Creator) - Florey Institute of Neuroscience and Mental HealthR.N. Martins (Author/Creator) - Edith Cowan UniversityY. Kanagasingam (Author/Creator) - Digital Productivity Flagship
- Publication Details
- Current Alzheimer Research, Vol.13(11), pp.1259-1266
- Publisher
- Bentham Science Publishers
- Identifiers
- 991005544585807891
- Copyright
- © 2016 Bentham Science Publishers
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.36 Ophthalmology
- 1.36.212 Genetic Retinopathies
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior