Amino Acid Patterns Within Short Consensus Repeats Define Conserved Duplicons Shared by Genes of the RCA Complex

C.A. McLure; R.L. Dawkins; J.F. Williamson; R.A Davies; J. Berry; N. Longman-Jacobsen; R. Laird; S. Gaudieri

doi:10.1007/s00239-004-2609-8

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Amino Acid Patterns Within Short Consensus Repeats Define Conserved Duplicons Shared by Genes of the RCA Complex

Journal article

Peer reviewed

Amino Acid Patterns Within Short Consensus Repeats Define Conserved Duplicons Shared by Genes of the RCA Complex

C.A. McLure, R.L. Dawkins, J.F. Williamson, R.A Davies, J. Berry, N. Longman-Jacobsen, R. Laird and S. Gaudieri

Journal of Molecular Evolution, Vol.59(2), pp.143-157

2004

DOI: https://doi.org/10.1007/s00239-004-2609-8

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Abstract

Complement control proteins (CCPs) contain repeated protein domains, short consensus repeats (SCRs), which must be relevant to diverse functions such as complement activation, coagulation, viral binding, fetal implantation, and self–nonself recognition. Although SCRs share some discontinuous and imperfect motifs, there are many variable positions and indels making classification in subfamilies extremely difficult. Using domain-by-domain phylogenetic analysis, we have found that most domains can be classified into only 11 subfamilies, designated a, b, c, d, e, f, g, h, i, j, or k and identified by critical residues. Each particular CCP is characterized by the order of representatives of the subfamilies. Human complement receptor 1 (CR1) has ajefbkd repeated four times and followed by ch. The classification crosses CCPs and indicates that a particular CCP is a function of the mix of SCRs. The aje set is a feature of several CCPs including human CR1 and DAF and murine Crry and appears to be associated with the success or failure of implantation inter alia. This approach facilitates genomic analysis of available sequences and suggests a framework for the evolution of CCPs. Units of duplication range from single SCRs, to septamers such as efbkdaj, to extensive segments such as MCP-CR1L. Imperfections of duplication with subsequent deletion have contributed to diversification.

Details

Title: Amino Acid Patterns Within Short Consensus Repeats Define Conserved Duplicons Shared by Genes of the RCA Complex
Authors/Creators: C.A. McLure (Author/Creator) - The University of Western Australia
R.L. Dawkins (Author/Creator) - The University of Western Australia
J.F. Williamson (Author/Creator) - The University of Western Australia
R.A Davies (Author/Creator) - The University of Western Australia
J. Berry (Author/Creator) - The University of Western Australia
N. Longman-Jacobsen (Author/Creator)
R. Laird (Author/Creator)
S. Gaudieri (Author/Creator) - The University of Western Australia
Publication Details: Journal of Molecular Evolution, Vol.59(2), pp.143-157
Publisher: Springer-Verlag
Identifiers: 991005540056307891
Copyright: © Springer International Publishing AG.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.286 Immunology & Hematology; 1.286.845 Complement System
Web Of Science research areas: Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity
ESI research areas: Molecular Biology & Genetics