Journal article
Amitraz depresses cardiovascular responses to bilateral carotid occlusion
Journal of Veterinary Pharmacology and Therapeutics, Vol.19(1), pp.22-26
1996
Abstract
The ectoparasiticide amitraz stimulates α2,-adrenoceptors to produce side-effects such as bradycardia and hypotension. The actions of amitraz on baroreceptor reflex responses were evaluated in mongrel dogs by occlusion of both carotid arteries for 30-s periods. Incremental doses of amitraz given intravenously showed that doses of 60 μg/kg and above significantly depressed pressor responses to carotid occlusion. By comparison, 2 μg/kg amitraz given by intracisterna magna (i.c.m.) injection significantly depressed both blood pressure and heart rate responses. Pretreatment of dogs with i.c.m. yohimbine (30 μg/kg) prevented the depressant effects of amitraz on the reflex, but prazosin (20 μg/kg), in separate experiments, had no effect.
Details
- Title
- Amitraz depresses cardiovascular responses to bilateral carotid occlusion
- Authors/Creators
- J.A. Reynoldson (Author/Creator)L.K. Cullen (Author/Creator)
- Publication Details
- Journal of Veterinary Pharmacology and Therapeutics, Vol.19(1), pp.22-26
- Publisher
- Blackwell Publishing
- Identifiers
- 991005540607107891
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.32 Entomology
- 3.32.829 Juvenile Hormone
- Web Of Science research areas
- Pharmacology & Pharmacy
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science