Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease

J. Chhatwal; P. Chrem; H. Chui; J. Cinco; J. Clifford; C. Cruchaga; M. D‘Mello; T. Donahue; J. Douglas; N. Edigo; N. Erekin-Taner; A. Fagan; M. Farlow; A. Farrar; H. Feldman; G. Flynn; N. Fox; E. Franklin; H. Fujii; C. Gant; S. Gardener; B. Ghetti; A. Goate; J. Goldman; B. Gordon; N. Graff-Radford; J. Gray; J. Gurney; J. Hassenstab; M. Hirohara; D. Holtzman; R. Hornbeck; S.H. DiBari; T. Ikeuchi; S. Ikonomovic; G. Jerome; M. Jucker; C. Karch; K. Kasuga; T. Kawarabayashi; W. Klunk; R. Koeppe; E. Kuder-Buletta; C. Laske; J-H Lee; J. Levin; D. Marcus; R. Martins; N.S. Mason; C. Masters; D. Maue-Dreyfus; E. McDade; L. Montoya; H. Mori; J. Morris; A. Nagamatsu; K. Neimeyer; J. Noble; J. Norton; R. Perrin; M. Raichle; J. Ringman; J.H. Roh; S. Salloway; P. Schofield; H. Shimada; T. Shiroto; M. Shoji; W. Sigurdson; H. Sohrabi; P. Sparks; K. Suzuki; L. Swisher; K. Taddei; J. Wang; P. Wang; M. Weiner; M. Wolfsberger; C. Xiong; X. Xu; A. Tam; A. Labonté; A. Pichet Binette; A-M Faubert; A. Mathieu; C. Madjar; C.E. Carrier; C. Dansereau; C. Kazazian; C. Lepage; C. Picard; D. Maillet; D. Michaud; D. Couture; D. Dea; C. Cuello; A. Barkun; A. Evans; B. Courcot; C. Tardif; C. Debacker; C.R. Jack; D. Fontaine; D.S. Knopman; G. Maultaup; J. Near; J-M Leoutsakos; J-R Maltais; J. Brandt; J. Pruessner; J.C. Morris; J.C.S. Breitner; J. Poirier; L. Cheewakriengkrai; L-M Münter; L. Collins; M. Chakravarty; M.A. Sager; M. Dauar-Tedeschi; M. Eisenberg; N. Rajah; É. Vachon-Presseau; P. Aisen; J. Toussaint; R. Bateman; P. Rosa-Neto; P. Bellec; T. Benzinger; D.L. Collins; P. Kostopoulos; P. Etienne; P.N. Tariot; S. Villeneuve; P. Orban; R. Allegri; R.A. Sperling; F. Amtashar; R. Hoge; R.G. Thomas; S. Gauthier; S. Berman; S. Craft; C. Bodge; S. Brandon; T.J. Montine; W. Brooks; V. Nair; Jill Buck; V. Bohbot; V. Buckles; V. Venugopalan; S. Chea; V. Fonov; Y. Ituria-Medina; Z.S. Khachaturian; E. Teigner; E. Anthal; E. Yu; F. Ferdinand; G. Pogossova; G. Mayrand; G. Duclair; G. Gagné; H. Newbold-Fox; I. Leppert; I. Vallée; J.W. Vogel; J. Tremblay-Mercier; J. Frenette; J. Frappier; J. Kat; J. Miron; K. Wan; L. Mahar; L. Carmo; L. Théroux; M. Dadar; M. Dufour; M-E Lafaille-Magnan; M. Appleby; M. Savard; M. Tuwaig; M. Petkova; P. Rioux; P-F Meyer; R. El-Khoury; R. Gordon; R. Giles; S. Das; S. Wang; S. Tabrizi; S. Mathotaarachchi; S. Dubuc; T. Lee; T. Beaudry; V. Gervais; V. Pagé; J. Gonneaud; G. Ayranci; T.A. Pascoal; R. Desautels; F. Benbouhoud; E.F. Saint-Fort; S.C.J. Verfaillie; S. Farzin; A. Salaciak; S. Tullo; E. Vachon-Presseau; L-A Daoust; T. Köbe; N. Spreng; M. McSweeney; N. Nilsson; M. Pishnamazi; C. Bedetti

doi:10.1016/j.biopsych.2020.01.023

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Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease

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Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease

J. Chhatwal, P. Chrem, H. Chui, J. Cinco, J. Clifford, C. Cruchaga, M. D‘Mello, T. Donahue, J. Douglas, N. Edigo, …

Biological Psychiatry, Vol.89(8), pp.776-785

2021

DOI: https://doi.org/10.1016/j.biopsych.2020.01.023

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Abstract

Background Major prevention trials for Alzheimer’s disease (AD) are now focusing on multidomain lifestyle interventions. However, the exact combination of behavioral factors related to AD pathology remains unclear. In 2 cohorts of cognitively unimpaired individuals at risk of AD, we examined which combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle (years of education or lifetime cognitive activity) related to the pathological hallmarks of AD, amyloid-β, and tau deposits. Methods A total of 115 older adults with a parental or multiple-sibling family history of sporadic AD (PREVENT-AD [PRe-symptomatic EValuation of Experimental or Novel Treatments for AD] cohort) underwent amyloid and tau positron emission tomography and answered several questionnaires related to behavioral attributes. Separately, we studied 117 mutation carriers from the DIAN (Dominant Inherited Alzheimer Network) study group cohort with amyloid positron emission tomography and behavioral data. Using partial least squares analysis, we identified latent variables relating amyloid or tau pathology with combinations of personality traits, neuropsychiatric symptoms, and cognitive lifestyle. Results In PREVENT-AD, lower neuroticism, neuropsychiatric burden, and higher education were associated with less amyloid deposition (p = .014). Lower neuroticism and neuropsychiatric features, along with higher measures of openness and extraversion, were related to less tau deposition (p = .006). In DIAN, lower neuropsychiatric burden and higher education were also associated with less amyloid (p = .005). The combination of these factors accounted for up to 14% of AD pathology. Conclusions In the preclinical phase of both sporadic and autosomal dominant AD, multiple behavioral features were associated with AD pathology. These results may suggest potential pathways by which multidomain interventions might help delay AD onset or progression.

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Title: Amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant Alzheimer’s disease
Authors/Creators: J. Chhatwal (Author/Creator)
P. Chrem (Author/Creator)
H. Chui (Author/Creator)
J. Cinco (Author/Creator)
J. Clifford (Author/Creator)
C. Cruchaga (Author/Creator)
M. D‘Mello (Author/Creator)
T. Donahue (Author/Creator)
J. Douglas (Author/Creator)
N. Edigo (Author/Creator)
N. Erekin-Taner (Author/Creator)
A. Fagan (Author/Creator)
M. Farlow (Author/Creator)
A. Farrar (Author/Creator)
H. Feldman (Author/Creator)
G. Flynn (Author/Creator)
N. Fox (Author/Creator)
E. Franklin (Author/Creator)
H. Fujii (Author/Creator)
C. Gant (Author/Creator)
S. Gardener (Author/Creator)
B. Ghetti (Author/Creator)
A. Goate (Author/Creator)
J. Goldman (Author/Creator)
B. Gordon (Author/Creator)
N. Graff-Radford (Author/Creator)
J. Gray (Author/Creator)
J. Gurney (Author/Creator)
J. Hassenstab (Author/Creator)
M. Hirohara (Author/Creator)
D. Holtzman (Author/Creator)
R. Hornbeck (Author/Creator)
S.H. DiBari (Author/Creator)
T. Ikeuchi (Author/Creator)
S. Ikonomovic (Author/Creator)
G. Jerome (Author/Creator)
M. Jucker (Author/Creator)
C. Karch (Author/Creator)
K. Kasuga (Author/Creator)
T. Kawarabayashi (Author/Creator)
W. Klunk (Author/Creator)
R. Koeppe (Author/Creator)
E. Kuder-Buletta (Author/Creator)
C. Laske (Author/Creator)
J-H Lee (Author/Creator)
J. Levin (Author/Creator)
D. Marcus (Author/Creator)
R. Martins (Author/Creator)
N.S. Mason (Author/Creator)
C. Masters (Author/Creator)
D. Maue-Dreyfus (Author/Creator)
E. McDade (Author/Creator)
L. Montoya (Author/Creator)
H. Mori (Author/Creator)
J. Morris (Author/Creator) - Washington University in St. Louis
A. Nagamatsu (Author/Creator)
K. Neimeyer (Author/Creator)
J. Noble (Author/Creator)
J. Norton (Author/Creator)
R. Perrin (Author/Creator)
M. Raichle (Author/Creator)
J. Ringman (Author/Creator)
J.H. Roh (Author/Creator)
S. Salloway (Author/Creator)
P. Schofield (Author/Creator)
H. Shimada (Author/Creator)
T. Shiroto (Author/Creator)
M. Shoji (Author/Creator)
W. Sigurdson (Author/Creator)
H. Sohrabi (Author/Creator)
P. Sparks (Author/Creator)
K. Suzuki (Author/Creator)
L. Swisher (Author/Creator)
K. Taddei (Author/Creator)
J. Wang (Author/Creator)
P. Wang (Author/Creator)
M. Weiner (Author/Creator)
M. Wolfsberger (Author/Creator)
C. Xiong (Author/Creator)
X. Xu (Author/Creator)
A. Tam (Author/Creator)
A. Labonté (Author/Creator)
A. Pichet Binette (Author/Creator)
A-M Faubert (Author/Creator)
A. Mathieu (Author/Creator)
C. Madjar (Author/Creator)
C.E. Carrier (Author/Creator)
C. Dansereau (Author/Creator)
C. Kazazian (Author/Creator)
C. Lepage (Author/Creator)
C. Picard (Author/Creator)
D. Maillet (Author/Creator)
D. Michaud (Author/Creator)
D. Couture (Author/Creator)
D. Dea (Author/Creator)
C. Cuello (Author/Creator)
A. Barkun (Author/Creator)
A. Evans (Author/Creator)
B. Courcot (Author/Creator)
C. Tardif (Author/Creator)
C. Debacker (Author/Creator)
C.R. Jack (Author/Creator)
D. Fontaine (Author/Creator)
D.S. Knopman (Author/Creator)
G. Maultaup (Author/Creator)
J. Near (Author/Creator)
J-M Leoutsakos (Author/Creator)
J-R Maltais (Author/Creator)
J. Brandt (Author/Creator)
J. Pruessner (Author/Creator)
J.C. Morris (Author/Creator) - Washington University in St. Louis
J.C.S. Breitner (Author/Creator) - McGill University
J. Poirier (Author/Creator) - McGill University
L. Cheewakriengkrai (Author/Creator)
L-M Münter (Author/Creator)
L. Collins (Author/Creator)
M. Chakravarty (Author/Creator)
M.A. Sager (Author/Creator)
M. Dauar-Tedeschi (Author/Creator)
M. Eisenberg (Author/Creator)
A. Pichet Binette (Author/Creator)
N. Rajah (Author/Creator)
É. Vachon-Presseau (Author/Creator) - McGill University
P. Aisen (Author/Creator)
J. Morris (Author/Creator) - Washington University in St. Louis
J. Toussaint (Author/Creator)
R. Bateman (Author/Creator) - Washington University in St. Louis
P. Rosa-Neto (Author/Creator)
P. Bellec (Author/Creator)
T. Benzinger (Author/Creator)
D.L. Collins (Author/Creator) - Montreal Neurological Institute and Hospital
P. Kostopoulos (Author/Creator)
J. Poirier (Author/Creator) - McGill University
P. Etienne (Author/Creator)
J.C.S. Breitner (Author/Creator) - McGill University
P.N. Tariot (Author/Creator)
S. Villeneuve (Author/Creator) - McGill University
P. Orban (Author/Creator)
R. Allegri (Author/Creator)
R.A. Sperling (Author/Creator)
F. Amtashar (Author/Creator)
R. Hoge (Author/Creator)
R. Bateman (Author/Creator) - Washington University in St. Louis
R.G. Thomas (Author/Creator)
T. Benzinger (Author/Creator)
S. Gauthier (Author/Creator)
S. Berman (Author/Creator)
S. Craft (Author/Creator)
C. Bodge (Author/Creator)
S. Villeneuve (Author/Creator) - McGill University
S. Brandon (Author/Creator)
T.J. Montine (Author/Creator)
W. Brooks (Author/Creator)
V. Nair (Author/Creator)
Jill Buck (Author/Creator)
V. Bohbot (Author/Creator)
V. Buckles (Author/Creator)
V. Venugopalan (Author/Creator)
S. Chea (Author/Creator)
V. Fonov (Author/Creator)
Y. Ituria-Medina (Author/Creator)
Z.S. Khachaturian (Author/Creator)
E. Teigner (Author/Creator)
E. Anthal (Author/Creator)
E. Yu (Author/Creator)
F. Ferdinand (Author/Creator)
G. Pogossova (Author/Creator)
G. Mayrand (Author/Creator)
G. Duclair (Author/Creator)
G. Gagné (Author/Creator)
H. Newbold-Fox (Author/Creator)
I. Leppert (Author/Creator)
I. Vallée (Author/Creator)
J.W. Vogel (Author/Creator)
J. Tremblay-Mercier (Author/Creator)
J. Frenette (Author/Creator)
J. Frappier (Author/Creator)
J. Kat (Author/Creator)
J. Miron (Author/Creator)
K. Wan (Author/Creator)
L. Mahar (Author/Creator)
L. Carmo (Author/Creator)
L. Théroux (Author/Creator)
M. Dadar (Author/Creator)
M. Dufour (Author/Creator)
M-E Lafaille-Magnan (Author/Creator)
M. Appleby (Author/Creator)
M. Savard (Author/Creator)
M. Tuwaig (Author/Creator)
M. Petkova (Author/Creator)
P. Rioux (Author/Creator)
P-F Meyer (Author/Creator)
R. El-Khoury (Author/Creator)
R. Gordon (Author/Creator)
R. Giles (Author/Creator)
S. Das (Author/Creator)
S. Wang (Author/Creator)
S. Tabrizi (Author/Creator)
S. Mathotaarachchi (Author/Creator)
S. Dubuc (Author/Creator)
T. Lee (Author/Creator)
T. Beaudry (Author/Creator)
V. Gervais (Author/Creator)
V. Pagé (Author/Creator)
J. Gonneaud (Author/Creator)
G. Ayranci (Author/Creator)
T.A. Pascoal (Author/Creator)
R. Desautels (Author/Creator)
F. Benbouhoud (Author/Creator)
E.F. Saint-Fort (Author/Creator)
S.C.J. Verfaillie (Author/Creator)
S. Farzin (Author/Creator)
A. Salaciak (Author/Creator)
S. Tullo (Author/Creator)
E. Vachon-Presseau (Author/Creator) - McGill University
L-A Daoust (Author/Creator)
T. Köbe (Author/Creator)
N. Spreng (Author/Creator)
M. McSweeney (Author/Creator)
N. Nilsson (Author/Creator)
M. Pishnamazi (Author/Creator)
C. Bedetti (Author/Creator)
Publication Details: Biological Psychiatry, Vol.89(8), pp.776-785
Publisher: Elsevier
Identifiers: 991005542949407891
Copyright: © 2020 Society of Biological Psychiatry
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Web Of Science research areas: Neurosciences; Psychiatry
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