Journal article
Amyloid burden and incident depressive symptoms in cognitively normal older adults
International Journal of Geriatric Psychiatry, Vol.32(4), pp.455-463
2016
Abstract
Objective
Several studies have reported that non‐demented older adults with clinical depression show changes in amyloid‐β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54‐month prospective observation period.
Methods
Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale — Short Form at 18‐month intervals over 54 months.
Results
Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3–16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54‐month assessment.
Conclusions
Results of this study suggest that elevated Aβ levels are associated with a 4.5‐fold increased likelihood of developing clinically significant depressive symptoms on follow‐up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ.
Details
- Title
- Amyloid burden and incident depressive symptoms in cognitively normal older adults
- Authors/Creators
- K.D. Harrington (Author/Creator) - The University of MelbourneE. Gould (Author/Creator) - Deakin UniversityY.Y. Lim (Author/Creator) - The University of MelbourneD. Ames (Author/Creator) - The University of MelbourneR.H. Pietrzak (Author/Creator) - Yale UniversityA. Rembach (Author/Creator) - The University of MelbourneS. Rainey-Smith (Author/Creator)R.N. Martins (Author/Creator) - Edith Cowan UniversityO. Salvado (Author/Creator) - Australian e-Health Research CentreV.L. Villemagne (Author/Creator) - The University of MelbourneC.C. Rowe (Author/Creator) - The University of MelbourneC.L. Masters (Author/Creator) - The University of MelbourneP. Maruff (Author/Creator) - The University of Melbourne
- Publication Details
- International Journal of Geriatric Psychiatry, Vol.32(4), pp.455-463
- Publisher
- John Wiley & Sons Ltd
- Identifiers
- 991005544342807891
- Copyright
- © 2016 John Wiley & Sons, Ltd.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Geriatrics & Gerontology
- Gerontology
- Psychiatry
- ESI research areas
- Psychiatry/Psychology