An Aboriginal Australian genome reveals separate human dispersals into Asia

M. Rasmussen; X. Guo; Y. Wang; K.E. Lohmueller; S. Rasmussen; A. Albrechtsen; L. Skotte; S. Lindgreen; M. Metspalu; T. Jombart; T. Kivisild; W. Zhai; A. Eriksson; A. Manica; L. Orlando; F.M. De La Vega; S. Tridico; E. Metspalu; K. Nielsen; M.C. Avila-Arcos; J.V. Moreno-Mayar; C. Muller; J. Dortch; M.T.P. Gilbert; O. Lund; A. Wesolowska; M. Karmin; L.A. Weinert; B. Wang; J. Li; S. Tai; F. Xiao; T. Hanihara; G. van Driem; A.R. Jha; F-X. Ricaut; P. de Knijff; A.B. Migliano; I. Gallego Romero; K. Kristiansen; D.M. Lambert; S. Brunak; P. Forster; B. Brinkmann; O. Nehlich; M. Bunce; M. Richards; R. Gupta; C.D. Bustamante; A. Krogh; R.A. Foley; M.M. Lahr; F. Balloux; T. Sicheritz-Ponten; R. Villems; R. Nielsen; J. Wang; E. Willerslev

doi:10.1126/science.1211177

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An Aboriginal Australian genome reveals separate human dispersals into Asia

Journal article

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An Aboriginal Australian genome reveals separate human dispersals into Asia

M. Rasmussen, X. Guo, Y. Wang, K.E. Lohmueller, S. Rasmussen, A. Albrechtsen, L. Skotte, S. Lindgreen, M. Metspalu, T. Jombart, …

Science, Vol.334(6052), pp.94-98

2011

DOI: https://doi.org/10.1126/science.1211177

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Abstract

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

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Title: An Aboriginal Australian genome reveals separate human dispersals into Asia
Authors/Creators: M. Rasmussen (Author/Creator) - University of Copenhagen
X. Guo (Author/Creator) - University of Copenhagen
Y. Wang (Author/Creator) - University of California, Berkeley
K.E. Lohmueller (Author/Creator) - University of California, Berkeley
S. Rasmussen (Author/Creator) - Technical University of Denmark
A. Albrechtsen (Author/Creator) - University of Copenhagen
L. Skotte (Author/Creator) - University of Copenhagen
S. Lindgreen (Author/Creator) - University of Copenhagen
M. Metspalu (Author/Creator) - Estonian Biocentre
T. Jombart (Author/Creator) - Imperial College London
T. Kivisild (Author/Creator) - University of Cambridge
W. Zhai (Author/Creator) - Chinese Academy of Sciences
A. Eriksson (Author/Creator) - University of Cambridge
A. Manica (Author/Creator) - University of Cambridge
L. Orlando (Author/Creator) - University of Copenhagen
F.M. De La Vega (Author/Creator) - Stanford University
S. Tridico (Author/Creator) - Murdoch University
E. Metspalu (Author/Creator) - Estonian Biocentre
K. Nielsen (Author/Creator) - Technical University of Denmark
M.C. Avila-Arcos (Author/Creator) - University of Copenhagen
J.V. Moreno-Mayar (Author/Creator) - Universidad Nacional Autónoma de México
C. Muller (Author/Creator)
J. Dortch (Author/Creator) - The University of Western Australia
M.T.P. Gilbert (Author/Creator) - University of Copenhagen
O. Lund (Author/Creator) - Technical University of Denmark
A. Wesolowska (Author/Creator) - Technical University of Denmark
M. Karmin (Author/Creator) - Estonian Biocentre
L.A. Weinert (Author/Creator) - Imperial College London
B. Wang (Author/Creator)
J. Li (Author/Creator)
S. Tai (Author/Creator)
F. Xiao (Author/Creator)
T. Hanihara (Author/Creator) - Kitasato University
G. van Driem (Author/Creator) - University of Bern
A.R. Jha (Author/Creator) - University of Chicago
F-X. Ricaut (Author/Creator) - Université Fédérale de Toulouse Midi-Pyrénées
P. de Knijff (Author/Creator) - Leiden University
A.B. Migliano (Author/Creator) - University of Cambridge
I. Gallego Romero (Author/Creator)
K. Kristiansen (Author/Creator) - University of Copenhagen
D.M. Lambert (Author/Creator) - Griffith University
S. Brunak (Author/Creator) - Technical University of Denmark
P. Forster (Author/Creator) - University of Cambridge
B. Brinkmann (Author/Creator)
O. Nehlich (Author/Creator) - Max Planck Society
M. Bunce (Author/Creator) - Murdoch University
M. Richards (Author/Creator) - University of British Columbia
R. Gupta (Author/Creator) - Technical University of Denmark
C.D. Bustamante (Author/Creator) - Stanford University
A. Krogh (Author/Creator) - University of Copenhagen
R.A. Foley (Author/Creator) - University of Cambridge
M.M. Lahr (Author/Creator) - University of Cambridge
F. Balloux (Author/Creator) - Imperial College London
T. Sicheritz-Ponten (Author/Creator) - Technical University of Denmark
R. Villems (Author/Creator) - Estonian Biocentre
R. Nielsen (Author/Creator) - University of California, Berkeley
J. Wang (Author/Creator)
E. Willerslev (Author/Creator) - University of Copenhagen
Publication Details: Science, Vol.334(6052), pp.94-98
Publisher: American Association for the Advancement of Science
Identifiers: 991005540242407891
Murdoch Affiliation: School of Biological Sciences and Biotechnology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.189 Genome Studies; 1.189.310 Population Genetics
Web Of Science research areas: Genetics & Heredity
ESI research areas: Molecular Biology & Genetics