Files and links (1)
CC BY V4.0, Open Access
Journal article
An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study
Metabolites, Vol.12(12), Art. 1206
2022
PMID: 36557244
Abstract
After SARS-CoV-2 infection, the molecular phenoreversion of the immunological response and its associated metabolic dysregulation are required for a full recovery of the patient. This process is patient-dependent due to the manifold possibilities induced by virus severity, its phylogenic evolution and the vaccination status of the population. We have here investigated the natural history of COVID-19 disease at the molecular level, characterizing the metabolic and immunological phenoreversion over time in large cohorts of hospitalized severe patients (n = 886) and non-hospitalized recovered patients that self-reported having passed the disease (n = 513). Non-hospitalized recovered patients do not show any metabolic fingerprint associated with the disease or immune alterations. Acute patients are characterized by the metabolic and lipidomic dysregulation that accompanies the exacerbated immunological response, resulting in a slow recovery time with a maximum probability of around 62 days. As a manifestation of the heterogeneity in the metabolic phenoreversion, age and severity become factors that modulate their normalization time which, in turn, correlates with changes in the atherogenesis-associated chemokine MCP-1. Our results are consistent with a model where the slow metabolic normalization in acute patients results in enhanced atherosclerotic risk, in line with the recent observation of an elevated number of cardiovascular episodes found in post-COVID-19 cohorts.
Details
- Title
- An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study
- Authors/Creators
- Ruben Gil-Redondo - CIC bioGUNERicardo Conde - CIC bioGUNEMaider Bizkarguenaga - CIC bioGUNEChiara Bruzzone - CIC bioGUNEAna Lain - CIC bioGUNEBeatriz Gonzalez-Valle - CIC bioGUNEMilagros Iriberri - Hosp Univ Cruces, Pneumol Dept, Baracaldo 48903, SpainCarlos Ramos-Acosta - Instituto de Investigación Sanitaria del Hospital Clínico San CarlosEduardo Anguita - Instituto de Investigación Sanitaria del Hospital Clínico San CarlosJuan Ignacio Arriaga Lariz - Hosp Univ Basurto, Pneumol Dept, Bilbao 48013, SpainPedro Pablo Espana Yandiola - Hosp Univ Galdakao Usansolo, Pneumol Dept, Galdakao 48960, SpainMiguel Angel Moran - Bioaraba Hlth Res Inst, Vitoria 01009, SpainMario Ernesto Jimenez-Mercado - Bioaraba Hlth Res Inst, Vitoria 01009, SpainLeire Egia-Mendikute - CIC bioGUNEMaria Luisa Seco - OSARTEN Kooperatiba Elkartea, Arrasate Mondragon 20500, SpainHartmut Schaefer - Bruker Biospin GmbH, D-76287 Silberstreifen, Rheinstetten, GermanyClaire Cannet - Bruker Biospin GmbH, D-76287 Silberstreifen, Rheinstetten, GermanyManfred Spraul - Bruker (United States)Asis Palazon - CIC bioGUNENieves Embade - CIC bioGUNEShelly C. Lu - College Station Medical CenterJulien Wist - Murdoch University, Centre for Computational and Systems MedicineJeremy K. Nicholson - Murdoch University, Health Futures InstituteJose M. Mato - CIC bioGUNEOscar Millet - CIC bioGUNE
- Publication Details
- Metabolites, Vol.12(12), Art. 1206
- Publisher
- MDPI
- Number of pages
- 15
- Grant note
- Department of Jobs, Tourism, Science and Innovation, Government of Western Australian Premier's Fellowship FP44842-221-2018 / Vicerrectoria de Investigaciones, Pontificia Universidad Javeriana, Bogota, Colombia McCusker Foundation, WA UK MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) SPRI I + D COVID-19 fund (Basque Government); Basque Government BIO21/COV/037 / BIOEF EITB Maratoia 2014349 / MRFF; Medical Research Future Fund (MRFF) ARC Laureate Fellowship; Australian Research Council ERC-2018-StG 804236-NEXTGEN-IO / European Research Council (ERC); European Commission 792-2017 / Ministerio de Educacion Nacional, Ministerio de Industria, Comercio y Turismo e ICETEX 2a Convocatoria Ecosistema Cientifico - Colombia Cientifica para la Financiacion de Proyectos de I + D + i DTS21/00094; RYC2018-024183-I / ISCiii; Instituto de Salud Carlos III Ministerio de Ciencia, Tecnologia e Innovacion (Minciencias) PID2019-107956RA-I00 / Spinnaker Health Research Foundation, WA Western Australian State Government
- Identifiers
- 991005564669707891
- Copyright
- © 2022 by the authors.
- Murdoch Affiliation
- Health Futures Institute; Australian National Phenome Centre; Centre for Computational and Systems Medicine
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
51 File views/ downloads
29 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 2 Chemistry
- 2.211 Mass Spectrometry
- 2.211.990 Metabolomics
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Biology & Biochemistry