An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

U. Dube; J.L. Del-Aguila; Z. Li; J.P. Budde; S. Jiang; S. Hsu; L. Ibanez; M.V. Fernandez; F. Farias; J. Norton; J. Gentsch; F. Wang; R. Allegri; F. Amtashar; T. Benzinger; S. Berman; C. Bodge; S. Brandon; W. Brooks; J. Buck; V. Buckles; S. Chea; P. Chrem; H. Chui; J. Cinco; J. Clifford; M. D'Mello; T. Donahue; J. Douglas; N. Edigo; N. Erekin-Taner; A. Fagan; M. Farlow; A. Farrar; H. Feldman; G. Flynn; N. Fox; E. Franklin; H. Fujii; C. Gant; S. Gardener; B. Ghetti; A. Goate; J. Goldman; B. Gordon; J. Gray; J. Gurney; J. Hassenstab; M. Hirohara; D. Holtzman; R. Hornbeck; S. Houeland DiBari; T. Ikeuchi; S. Ikonomovic; G. Jerome; M. Jucker; K. Kasuga; T. Kawarabayashi; W. Klunk; R. koeppe; E. Kuder-Buletta; C. Laske; J. Levin; D. Marcus; R. Martins; N.S. Mason; D. Maue-Dreyfus; E. McDade; L. Montoya; H. Mori; A. Nagamatsu; K. Neimeyer; J. Noble; R. Perrin; M. Raichle; J. Ringman; J-H Roh; P. Schofield; H. Shimada; T. Shiroto; M. Shoji; W. Sigurdson; H. Sohrabi; P. Sparks; K. Suzuki; L. Swisher; K. Taddei; J. Wang; P. Wang; M. Weiner; M. Wolfsberger; C. Xiong; X. Xu

doi:10.1038/s41593-019-0501-5

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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

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An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

U. Dube, J.L. Del-Aguila, Z. Li, J.P. Budde, S. Jiang, S. Hsu, L. Ibanez, M.V. Fernandez, F. Farias, J. Norton, …

Nature Neuroscience, Vol.22(11), pp.1903-1912

2019

DOI: https://doi.org/10.1038/s41593-019-0501-5

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Abstract

Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; ncontrol = 13; nAD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia severity and neuropathological severity. It was demonstrated that most circRNA–AD associations are independent of changes in cognate linear messenger RNA expression or estimated brain cell-type proportions. Evidence was provided for circRNA expression changes occurring early in presymptomatic AD and in autosomal dominant AD. It was also observed that AD-associated circRNAs co-expressed with known AD genes. Finally, potential microRNA-binding sites were identified in AD-associated circRNAs for miRNAs predicted to target AD genes. Together, these results highlight the importance of analyzing non-linear RNAs and support future studies exploring the potential roles of circRNAs in AD pathogenesis.

Details

Title: An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
Authors/Creators: U. Dube (Author/Creator)
J.L. Del-Aguila (Author/Creator)
Z. Li (Author/Creator)
J.P. Budde (Author/Creator)
S. Jiang (Author/Creator)
S. Hsu (Author/Creator)
L. Ibanez (Author/Creator)
M.V. Fernandez (Author/Creator)
F. Farias (Author/Creator)
J. Norton (Author/Creator)
J. Gentsch (Author/Creator)
F. Wang (Author/Creator)
R. Allegri (Author/Creator)
F. Amtashar (Author/Creator)
T. Benzinger (Author/Creator)
S. Berman (Author/Creator)
C. Bodge (Author/Creator)
S. Brandon (Author/Creator)
W. Brooks (Author/Creator)
J. Buck (Author/Creator)
V. Buckles (Author/Creator)
S. Chea (Author/Creator)
P. Chrem (Author/Creator)
H. Chui (Author/Creator)
J. Cinco (Author/Creator)
J. Clifford (Author/Creator)
M. D'Mello (Author/Creator)
T. Donahue (Author/Creator)
J. Douglas (Author/Creator)
N. Edigo (Author/Creator)
N. Erekin-Taner (Author/Creator)
A. Fagan (Author/Creator)
M. Farlow (Author/Creator)
A. Farrar (Author/Creator)
H. Feldman (Author/Creator)
G. Flynn (Author/Creator)
N. Fox (Author/Creator)
E. Franklin (Author/Creator)
H. Fujii (Author/Creator)
C. Gant (Author/Creator)
S. Gardener (Author/Creator)
B. Ghetti (Author/Creator)
A. Goate (Author/Creator)
J. Goldman (Author/Creator)
B. Gordon (Author/Creator)
J. Gray (Author/Creator)
J. Gurney (Author/Creator)
J. Hassenstab (Author/Creator)
M. Hirohara (Author/Creator)
D. Holtzman (Author/Creator)
R. Hornbeck (Author/Creator)
S. Houeland DiBari (Author/Creator)
T. Ikeuchi (Author/Creator)
S. Ikonomovic (Author/Creator)
G. Jerome (Author/Creator)
M. Jucker (Author/Creator)
K. Kasuga (Author/Creator)
T. Kawarabayashi (Author/Creator)
W. Klunk (Author/Creator)
R. koeppe (Author/Creator)
E. Kuder-Buletta (Author/Creator)
C. Laske (Author/Creator)
J. Levin (Author/Creator)
D. Marcus (Author/Creator)
R. Martins (Author/Creator)
N.S. Mason (Author/Creator)
D. Maue-Dreyfus (Author/Creator)
E. McDade (Author/Creator)
L. Montoya (Author/Creator)
H. Mori (Author/Creator)
A. Nagamatsu (Author/Creator)
K. Neimeyer (Author/Creator)
J. Noble (Author/Creator)
J. Norton (Author/Creator)
R. Perrin (Author/Creator)
M. Raichle (Author/Creator)
J. Ringman (Author/Creator)
J-H Roh (Author/Creator)
P. Schofield (Author/Creator)
H. Shimada (Author/Creator)
T. Shiroto (Author/Creator)
M. Shoji (Author/Creator)
W. Sigurdson (Author/Creator)
H. Sohrabi (Author/Creator)
P. Sparks (Author/Creator)
K. Suzuki (Author/Creator)
L. Swisher (Author/Creator)
K. Taddei (Author/Creator)
J. Wang (Author/Creator)
P. Wang (Author/Creator)
M. Weiner (Author/Creator)
M. Wolfsberger (Author/Creator)
C. Xiong (Author/Creator)
X. Xu (Author/Creator)
Publication Details: Nature Neuroscience, Vol.22(11), pp.1903-1912
Publisher: Nature Research
Identifiers: 991005542777107891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.196 Micro & Long Noncoding RNA; 1.196.921 lncRNA
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior