Journal article
An egg-hatch assay for resistance to levamisole in trichostrongyloid nematode parasites
Veterinary Parasitology, Vol.19(1-2), pp.77-84
1986
Abstract
An in vitro technique is described for detecting resistance of nematodes to the anthelmintic levamisole hydrochloride. Samples of eggs are developed under controlled temperature conditions until just prior to the commencement of hatching. They are then exposed to different concentrations of the drug and, when hatching is almost complete, the test samples are killed and preserved. The proportion of unhatched eggs at each drug concentration can then be counted at leisure. Provided a suitable range of drug concentrations is chosen for each test isolate, this assay provides results which may be satisfactorily fitted to a log-concentration-probit regression model. Comparisons with in vivo anthelmintic assays have shown that the technique provides an accurate reflection of the resistance status of parasite populations.
Details
- Title
- An egg-hatch assay for resistance to levamisole in trichostrongyloid nematode parasites
- Authors/Creators
- R.J. Dobson (Author/Creator)A.D. Donald (Author/Creator)P.J. Waller (Author/Creator)K.L. Snowdon (Author/Creator)
- Publication Details
- Veterinary Parasitology, Vol.19(1-2), pp.77-84
- Publisher
- Elsevier BV
- Identifiers
- 991005543020907891
- Copyright
- © 1986 Published by Elsevier B.V.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1022 Anthelmintic Resistance
- Web Of Science research areas
- Parasitology
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science