Journal article
An immunohistochemical study of canine disseminated aspergillosis
Australian Veterinary Journal, Vol.68(12), pp.383-386
1991
Abstract
An Immunohistochemical study of 25 lesions from 7 dogs with disseminated aspergillosis (Aspergillus terreus) is presented. All had multiple fungal granulomas in many viscera, with centres of necrotic tissue and hyphal elements surrounded by a mixed infiltrate of predominantly mononuclear cells.
Within these lesions, hyphae coated with immunoglobulin (IgG, IgM, IgA) and complement (C3, C4) were identified, together with perl-lesional mononuclear cells that reacted with antisera directed towards either IgG, IgM, IgA or a T lymphocyte marker (MUII).
A conspicuous feature was the prominent hyphal fluorescence seen with IgA and C3 antisera. The IgA reagent also marked large numbers of mononuclear cells both around lesions and scattered throughout Interstitial tissue, suggesting an abnormality of IgA production or regulation as a factor predisposing to this condition.
Details
- Title
- An immunohistochemical study of canine disseminated aspergillosis
- Authors/Creators
- M.J. Day (Author/Creator) - The University of Western AustraliaW.J. Penhale (Author/Creator) - Murdoch University
- Publication Details
- Australian Veterinary Journal, Vol.68(12), pp.383-386
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005540293907891
- Murdoch Affiliation
- School of Veterinary Studies
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.148 Medical Mycology
- 1.148.94 Antifungal Strategies
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science