Journal article
An updated review of the diagnostic methods in delayed drug hypersensitivity
Frontiers in Pharmacology, Vol.11, Art. 573573
2021
Abstract
Delayed drug hypersensitivity reactions are clinically diverse reactions that vary from isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug discontinuation or even continued drug treatment, to the other extreme of severe cutaneous adverse reactions (SCARs) that are associated with presumed life-long memory T-cell responses, significant acute and long-term morbidity and mortality. Diagnostic “in clinic” approaches to delayed hypersensitivity reactions have included patch testing (PT), delayed intradermal testing (IDT) and drug challenges for milder reactions. Patch and IDT are, in general, performed no sooner than 4–6 weeks after resolution of the acute reaction at the maximum non-irritating concentrations. Functional in vitro and ex vivo assays have largely remained the province of research laboratories and include lymphocyte transformation test (LTT) and cytokine release enzyme linked ImmunoSpot (ELISpot) assay, an emerging diagnostic tool which uses cytokine release, typically IFN-γ, after the patient’s peripheral blood mononuclear cells are stimulated with the suspected drug(s). Genetic markers such as human leukocyte antigen have shown recent promise for both pre-prescription screening as well as pre-emptive and diagnostic testing strategies.
Details
- Title
- An updated review of the diagnostic methods in delayed drug hypersensitivity
- Authors/Creators
- A. Copaescu (Author/Creator) - Austin HealthA. Gibson (Author/Creator) - Murdoch UniversityY. Li (Author/Creator) - Murdoch UniversityJ.A. Trubiano (Author/Creator) - Austin HealthE.J. Phillips (Author/Creator) - Murdoch University
- Publication Details
- Frontiers in Pharmacology, Vol.11, Art. 573573
- Publisher
- Frontiers Media S.A.
- Identifiers
- 991005545531907891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology