Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis

A. Rojana-udomsart; C. Mitrpant; I. James; C. Witt; M. Needham; T. Day; L. Kiers; A. Corbett; P. Martinez; S.D. Wilton; F.L. Mastaglia

doi:10.1016/j.jneuroim.2012.09.003

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Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis

Journal article

Peer reviewed

Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis

A. Rojana-udomsart, C. Mitrpant, I. James, C. Witt, M. Needham, T. Day, L. Kiers, A. Corbett, P. Martinez, S.D. Wilton, …

Journal of Neuroimmunology, Vol.254(1-2), pp.174-177

2013

DOI: https://doi.org/10.1016/j.jneuroim.2012.09.003

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Abstract

We compared the carriage frequencies of HLA-DRB3 and its major alleles and of HLA-DRB4 and HLA-DRB5 in an Australian sIBM cohort and a population control group who had previously been genotyped for the HLA-DRB1*03:01 risk allele. There was a strong disease association with the carriage of the DRB3*01:01 allele which was accounted for by its linkage disequilibrium with DRB1*03:01. The carriage of HLA-DRB4 was found to be strongly protective and abrogated the risk effect of HLA-DRB1*03:01. The findings indicate that haplotypic combinations of alleles at the HLA-DRB1 and secondary HLA-DRB loci have important risk modifying effects in sIBM.

Details

Title: Analysis of HLA-DRB3 alleles and supertypical genotypes in the MHC Class II region in sporadic inclusion body myositis
Authors/Creators: A. Rojana-udomsart (Author/Creator)
C. Mitrpant (Author/Creator)
I. James (Author/Creator)
C. Witt (Author/Creator)
M. Needham (Author/Creator)
T. Day (Author/Creator)
L. Kiers (Author/Creator)
A. Corbett (Author/Creator)
P. Martinez (Author/Creator)
S.D. Wilton (Author/Creator)
F.L. Mastaglia (Author/Creator)
Publication Details: Journal of Neuroimmunology, Vol.254(1-2), pp.174-177
Publisher: Elsevier
Identifiers: 991005545006207891
Copyright: © 2012 Elsevier B.V.
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.106 Rheumatology; 1.106.1684 Dermatomyositis
Web Of Science research areas: Immunology; Neurosciences
ESI research areas: Neuroscience & Behavior