Analysis of Jembrana disease virus mRNA transcripts produced during acute infection demonstrates a complex transcription pattern

M.E. Stewart; M. Desport; S. Setiyaningsih; N. Hartaningsih; G.E. Wilcox

doi:10.1016/j.virusres.2008.03.017

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Analysis of Jembrana disease virus mRNA transcripts produced during acute infection demonstrates a complex transcription pattern

Journal article

Peer reviewed

Analysis of Jembrana disease virus mRNA transcripts produced during acute infection demonstrates a complex transcription pattern

M.E. Stewart, M. Desport, S. Setiyaningsih, N. Hartaningsih and G.E. Wilcox

Virus Research, Vol.135(2), pp.336-339

2008

DOI: https://doi.org/10.1016/j.virusres.2008.03.017

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Abstract

Jembrana disease virus (JDV) is an unusual bovine lentivirus that causes an acute disease syndrome with a 20% case fatality rate after a short incubation period in Bos javanicus (Bali cattle) in Indonesia. Analysis of tatmRNA transcription patterns has identified up to six differently spliced transcripts indicating that, in common with other lentiviruses, JDV uses acomplex splicing pattern. RT-PCR analysis of mRNA transcripts produced during the acute phase of infection with JDVTAB/87 revealed at least 12 differently spliced transcripts involving 9 different splice sites. A single unspliced gag/pol transcript, singly spliced vif and tmx specific transcripts and alternatively spliced env, tat and rev transcripts were identified. A 67 nucleotide putative non-coding exon was identified that shared the same splice acceptor (SA) as vif and was incorporated into alternative transcripts of tat, rev and env.

Details

Title: Analysis of Jembrana disease virus mRNA transcripts produced during acute infection demonstrates a complex transcription pattern
Authors/Creators: M.E. Stewart (Author/Creator)
M. Desport (Author/Creator)
S. Setiyaningsih (Author/Creator)
N. Hartaningsih (Author/Creator)
G.E. Wilcox (Author/Creator)
Publication Details: Virus Research, Vol.135(2), pp.336-339
Publisher: Elsevier BV
Identifiers: 991005542485407891
Copyright: 2008 Elsevier BV
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

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Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.46 HIV Pathogenesis
Web Of Science research areas: Virology
ESI research areas: Microbiology