Journal article
Analysis of genetic variants of class II cytokine and their receptor genes in psoriasis patients of two ethnic groups from the Volga-Ural region of Russia
Journal of Dermatological Science, Vol.68(1), pp.9-18
2012
Abstract
Background
The molecular basis of pathogenesis of psoriasis remains unclear, but one unifying hypothesis of disease aetiology is the cytokine network model. The class II cytokines (CF2) and their receptors (CRF2) are all involved in the inflammatory processes and single nucleotide polymorphisms (SNPs) in respective genes have been associated with psoriasis in a previous study of the Estonian population.
Objective
We performed a replication study of 47 SNPs in CF2 and CRF2 genes in independent cohorts of psoriasis patients of two ethnic groups (Russians and Bashkirs) from the Volga-Ural region of Russia.
Methods
DNA was obtained from 395 psoriasis patients of two ethnic groups from the Volga-Ural region of Russia and 476 ethnically matched controls. 47 SNPs in the loci of the genes encoding Class II cytokines and their receptors were selected by SNPbrowser version 3.5. Genotyping was performed using the SNPlex™ (Applied Biosystems) platform.
Results
The genetic variant rs30461 previously associated in original case-control study in Estonians, was also associated in Russians (corrected P-value (Pc = 0.008, OR = 0.44), but did not reach statistical significance in the Bashkir population. Additionally, the haplotype analysis provided that CC haplotype formed by the SNPs rs30461 and rs955155 had a protective effect in Russians (Pc = 0.0024, OR = 0.44), supporting the involvement of this locus in the protection against psoriasis. Combined meta-analysis of three populations, including 943 psoriasis patients and 812 healthy controls, showed that the IL29 rs30461 C-allele was not associated with decreased risk of psoriasis (P = 0.165, OR = 0.68). Moreover, stratification of studies by ethnicity revealed a significant association in the European cohort (P = 9.506E−006, OR = 0.53).
Conclusion
Therefore, there is no overall evidence of association between psoriasis and SNP rs30461 of the IL29 gene, but there is some evidence to suggest that an association exists in Europeans. However, this current concept should be considered as preliminary and the results need to be confirmed in future independent studies.
Details
- Title
- Analysis of genetic variants of class II cytokine and their receptor genes in psoriasis patients of two ethnic groups from the Volga-Ural region of Russia
- Authors/Creators
- E. Galimova (Author/Creator) - Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, RussiaV. Akhmetova (Author/Creator) - Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, RussiaB. Latipov (Author/Creator) - UFA (United States)K. Kingo (Author/Creator) - University of TartuR. Rätsep (Author/Creator) - University of TartuT. Traks (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE. Khusnutdinova (Author/Creator) - Bashkir State University
- Publication Details
- Journal of Dermatological Science, Vol.68(1), pp.9-18
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 991005546004807891
- Copyright
- © 2012 Japanese Society for Investigative Dermatology.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.737 Psoriasis
- Web Of Science research areas
- Dermatology
- ESI research areas
- Clinical Medicine