Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements

K.J. Billingsley; F. Lättekivi; A. Planken; E. Reimann; L. Kurvits; L. Kadastik-Eerme; K.M. Kasterpalu; V.J. Bubb; J.P. Quinn; S. Kõks; P. Taba

doi:10.1038/s41598-019-40869-z

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Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements

Journal article

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Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements

K.J. Billingsley, F. Lättekivi, A. Planken, E. Reimann, L. Kurvits, L. Kadastik-Eerme, K.M. Kasterpalu, V.J. Bubb, J.P. Quinn, S. Kõks, …

Scientific Reports, Vol.9(1)

2019

DOI: https://doi.org/10.1038/s41598-019-40869-z

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Abstract

Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mutagenic threat. Despite reports that associate RE expression with PD no study has comprehensively analysed the role of these elements in the disease. This study presents the first genome-wide analysis of RE expression in PD to date. Analysis of RNA-sequencing data of 12 PD patients and 12 healthy controls identified tissue-specific expression differences and more significantly, differential expression of four satellite elements; two simple satellite III (repName = CATTC_n and _GAATG_n) a high-copy satellite II (HSATII) and a centromeric satellite (ALR_Alpha) in the blood of PD patients. In support of the growing body of recent evidence associating REs with neurodegenerative disease, this study highlights the potential importance of characterization of RE expression in such diseases.

Details

Title: Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements
Authors/Creators: K.J. Billingsley (Author/Creator) - University of Liverpool
F. Lättekivi (Author/Creator) - University of Tartu
A. Planken (Author/Creator) - University of Tartu
E. Reimann (Author/Creator) - University of Tartu
L. Kurvits (Author/Creator) - University of Tartu
L. Kadastik-Eerme (Author/Creator) - University of Tartu
K.M. Kasterpalu (Author/Creator) - Estonian National Defense College
V.J. Bubb (Author/Creator) - University of Liverpool
J.P. Quinn (Author/Creator) - University of Liverpool
S. Kõks (Author/Creator) - Perron Institute for Neurological and Translational Science
P. Taba (Author/Creator) - University of Tartu
Publication Details: Scientific Reports, Vol.9(1)
Publisher: Springer Nature
Identifiers: 991005544593907891
Copyright: © 2019 Springer Nature Publishing AG
Murdoch Affiliation: Centre for Comparative Genomics
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.54 Molecular & Cell Biology - Genetics; 1.54.1122 Transposable Elements
Web Of Science research areas: Clinical Neurology
ESI research areas: Molecular Biology & Genetics