Journal article
Analysis of single nucleotide polymorphisms at 13 loci within the transforming growth factor-induced factor gene shows no association with high myopia in Japanese subjects
Immunogenetics, Vol.58(12), pp.947-953
12/2006
Abstract
A previous study in China first indicated that the transforming growth factor-induced factor (TGIF) is a probable candidate gene for high myopia. The purpose of our study was to investigate whether there are significant associations between high myopia and single nucleotide polymorphism (SNP) variants in the TGIF gene of Japanese subjects. Genomic DNA was collected from 330 Japanese subjects with high myopia and at a level refractive error was less than -9.25 Dsph and 330 randomized controls without high myopia. Thirteen SNPs were detected by polymerase chain reaction (PCR) and primer extension or by PCR and SNP-specific fluorogenic probes in all of the cases and controls. Thirteen SNPs were found within the TGIF genes of the cases and controls. Two of the SNPs were monomorphic and none of the 13 SNPs showed a significant result. The pairwise linkage disequilibrium (LD) mapping confirmed that these alleles have a comparatively strong LD index of >0.8 for D′ and >0.4 for r 2. We found no statistical association between any of the 13 SNPs located on the TGIF gene and high myopia in Japanese subjects. Based on our study using Japanese subjects and the previous studies of TGIF gene polymorphism in Chinese and northern European subjects with myopia, there is no convincing evidence to prove a connection between nucleotide sequence variations in TGIF and high myopia.
Details
- Title
- Analysis of single nucleotide polymorphisms at 13 loci within the transforming growth factor-induced factor gene shows no association with high myopia in Japanese subjects
- Authors/Creators
- Y. Hasumi (Author/Creator)H. Inoko (Author/Creator) - Tokai UniversityS. Mano (Author/Creator) - Nagoya City UniversityM. Ota (Author/Creator) - Shinsyu University School of MedicineE. Okada (Author/Creator) - Okada Eye ClinicJ.K. Kulski (Author/Creator) - Tokai UniversityR. Nishizaki (Author/Creator) - Tokai UniversityJ. Mok (Author/Creator) - Catholic University of KoreaA. Oka (Author/Creator) - Tokai UniversityN. Kumagai (Author/Creator) - Yamaguchi UniversityT. Nishida (Author/Creator) - Yamaguchi UniversityS. Ohno (Author/Creator) - Hokkaido UniversityN. Mizuki (Author/Creator) - Yokohama City University
- Publication Details
- Immunogenetics, Vol.58(12), pp.947-953
- Publisher
- Springer-Verlag
- Identifiers
- 991005544956407891
- Copyright
- © 2006 Springer-Verlag.
- Murdoch Affiliation
- School of Information Technology
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.36 Ophthalmology
- 1.36.813 Vision Disorders
- Web Of Science research areas
- Genetics & Heredity
- Immunology
- ESI research areas
- Immunology