Journal article
Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on fatigue and depression
BMC Neurology, Vol.20(1), Art. 142
2020
Abstract
Background
Emotional health disturbances are common after aneurysmal subarachnoid hemorrhage (aSAH) and their causes are largely unexplored. Corticotropin-releasing hormone receptor 1 (CRHR1) is a key factor in stress reactivity and development of mental health disturbances after adverse life-events.
Methods
We explore the effect of CRHR1 genotype on mental health after aSAH in a retrospective cohort study. One hundred twenty-five patients have been assessed using EST-Q mental health questionnaire. Genotyping of CRHR1 single nucleotide polymorphisms (SNP-s) was performed (Rs7209436, Rs110402, Rs242924).
Results
Fatigue was present in almost half of aSAH patients, depression and anxiety in one-third. There was a high prevalence of insomnia and panic complaints. Rs110402 minor allele decreased the risk of depression (OR = 0.25, p = 0.027 for homozygotes). Depression was present in 14% vs 41% in minor and major allele homozygotes, respectively. Rs110402, Rs242924 and Rs7209436 minor alleles and TAT-haplotype, formed by them, were protective against fatigue. After Bonferroni correction only the association of Rs110402 with fatigue remained statistically significant (OR = 0.21, p = 0.006 for minor allele homozygotes). Results remained statistically significant when adjusted for gender, admission state, age and time from aSAH. In multiple regression analysis occurrence of fatigue was dependent on anxiety, modified Rankin score and Rs110402 genotype (R2 = 0.34, p < 0.001).
Conclusions
CRHR1 minor genotype was associated with a lower risk of fatigue and depression after aSAH. Genetic predisposition to mental health disturbances associated with negative life-events could be a risk factor for fatigue and depression after aSAH and selected patients might benefit from advanced counselling in the recovery phase.
Details
- Title
- Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on fatigue and depression
- Authors/Creators
- A. Vetkas (Author/Creator) - Tartu University HospitalE. Prans (Author/Creator) - University of TartuS. Kõks (Author/Creator) - Murdoch UniversityT. Rätsep (Author/Creator) - Tartu University HospitalT. Asser (Author/Creator) - Tartu University Hospital
- Publication Details
- BMC Neurology, Vol.20(1), Art. 142
- Publisher
- BioMed Central Ltd
- Identifiers
- 991005544591407891
- Copyright
- © 2020 The Author(s).
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
26 File views/ downloads
60 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.420 Stress and Cortisol
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior