Journal article
Anodal transcranial direct current stimulation reduces secondary hyperalgesia induced by low frequency electrical stimulation in healthy volunteers
The Journal of Pain, Vol.23(2), pp.305-317
2022
Abstract
The aim of the study was to determine whether transcranial direct current stimulation (tDCS) reduced pain and signs of central sensitization induced by low frequency electrical stimulation in healthy volunteers. Thirty-nine participants received tDCS stimulation under 4 different conditions: anodal tDCS of the primary motor cortex (M1), anodal tDCS of the dorsolateral prefrontal cortex (DLPFC), anodal tDCS over M1 and DLPFC concurrently, and sham tDCS. Participants were blind to the tDCS condition. The order of the conditions was randomized among participants. Pain ratings to pinpricks, the current level that evoked moderate pain, and pain induced by low frequency electrical stimulation were assessed in the forearm by an experimenter who was blind to the tDCS conditions. Anodal tDCS at M1 increased the current level that evoked moderate pain compared to sham and other conditions. Anodal tDCS of DLPFC completely abolished secondary hyperalgesia. Unexpectedly, however, concurrent anodal tDCS over M1 and DLPFC did not reduce pain or hyperalgesia more than M1 alone or DLPFC alone. Overall, these findings suggest that anodal tDCS over M1 suppresses pain, and that anodal tDCS over DLPFC modulates secondary hyperalgesia (a sign of central sensitization) in healthy participants.
Details
- Title
- Anodal transcranial direct current stimulation reduces secondary hyperalgesia induced by low frequency electrical stimulation in healthy volunteers
- Authors/Creators
- L. Vo (Author/Creator) - Murdoch UniversityN. Ilich (Author/Creator) - Murdoch UniversityH. Fujiyama (Author/Creator) - Murdoch UniversityP.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- The Journal of Pain, Vol.23(2), pp.305-317
- Publisher
- Elsevier
- Identifiers
- 991005541529207891
- Copyright
- © 2021 by United States Association for the Study of Pain, Inc.
- Murdoch Affiliation
- School of Allied Health
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.811 Transcranial Magnetic Stimulation
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior