Journal article
Anthropogenic and environmental factors associated with high incidence of mcr-1 carriage in humans across China
Nature Microbiology, Vol.3, pp.1054-1062
2018
Abstract
MCR-1-positve Escherichia coli (MCRPEC) have been reported in humans worldwide; however, thus far, their prevalence is low and potential sources for human mcr-1 carriage have not yet been identified. Here, we analyse a nationwide epidemiological dataset on MCRPEC in humans throughout China and assess the factors associated with MCRPEC carriage using natural and national anthropogenic data. We identified 774 non-duplicate MCRPEC isolates from 774 stool samples collected from 5,159 healthy individuals in 30 provinces and municipalities in 2016, with a prevalence of MCRPEC ranging from 3.7 to 32.7% (average: 15.0%)—substantially higher than previously reported. MCRPEC carriage was associated with provincial regions, the production of sheep and freshwater aquaculture, annual consumption of total meat, pork and mutton, and daily intake of aquaculture products. MCRPEC was significantly more prevalent in provinces with higher aquaculture industries. Whole-genome sequencing analysis revealed that the MCRPEC isolates were clustered into four distinct lineages, two of which were dominant and harboured most of the MCRPEC isolates. The high prevalence of MCRPEC in the community poses a substantial risk for colistin usage in clinical practice and suggests the need for intestinal screening of mcr-1 carriers in intensive care units in Chinese hospitals. Furthermore, our data suggest that aquaculture is a significant reservoir of mcr-1.
Details
- Title
- Anthropogenic and environmental factors associated with high incidence of mcr-1 carriage in humans across China
- Authors/Creators
- Y. Shen (Author/Creator) - China Agricultural UniversityH. Zhou (Author/Creator) - Second Affiliated Hospital of Zhejiang UniversityJ. Xu (Author/Creator) - Chinese Center For Disease Control and PreventionY. Wang (Author/Creator) - China Agricultural UniversityQ. Zhang (Author/Creator) - Iowa State UniversityT.R. Walsh (Author/Creator) - Institute of Infection and ImmunityB. Shao (Author/Creator) - China Agricultural UniversityC. Wu (Author/Creator) - China Agricultural UniversityY. Hu (Author/Creator) - Second Affiliated Hospital of Zhejiang UniversityL. Yang (Author/Creator) - China Agricultural UniversityZ. Shen (Author/Creator) - China Agricultural UniversityZ. Wu (Author/Creator) - Iowa State UniversityQ. Sun (Author/Creator) - Second Affiliated Hospital of Zhejiang UniversityY. Ou (Author/Creator) - China Agricultural UniversityY. Wang (Author/Creator) - China Agricultural UniversityS. Wang (Author/Creator) - China Agricultural UniversityY. Wu (Author/Creator) - China National Center for Food Safety Risk AssessmentC. Cai (Author/Creator) - Murdoch UniversityJ. Li (Author/Creator)J. Shen (Author/Creator) - China Agricultural UniversityR. Zhang (Author/Creator) - Second Affiliated Hospital of Zhejiang UniversityY. Wang (Author/Creator) - China Agricultural University
- Publication Details
- Nature Microbiology, Vol.3, pp.1054-1062
- Publisher
- Nature Publishing Group
- Identifiers
- 991005542032507891
- Copyright
- © 2018 The Author(s)
- Murdoch Affiliation
- School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
82 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.23 Antibiotics & Antimicrobials
- 1.23.146 Antimicrobial Resistance
- Web Of Science research areas
- Microbiology
- ESI research areas
- Microbiology