Journal article
Anti-retroviral effects of type I IFN subtypes in vivo
European Journal of Immunology, Vol.39(1), pp.136-146
2009
Abstract
Type I IFN play a very important role in immunity against viral infections. Murine type I IFN belongs to a multigene family including 14 IFN-α subtypes but the biological functions of IFN-α subtypes in retroviral infections are unknown. We have used the Friend retrovirus model to determine the anti-viral effects of IFN-α subtypes in vitro and in vivo. IFN-α subtypes α1, α4, α6 or α9 suppressed Friend virus (FV) replication in vitro, but differed greatly in their anti-viral efficacy in vivo. Treatment of FV-infected mice with the IFN-α subtypes α1, α4 or α9, but not α6 led to a significant reduction in viral loads. Decreased splenic viral load after IFN-α1 treatment correlated with an expansion of activated FV-specific CD8+ T cells and NK cells into the spleen, whereas in IFN-α4- and -α9-treated mice it exclusively correlated with the activation of NK cells. The results demonstrate the distinct anti-retroviral effects of different IFN-α subtypes, which may be relevant for new therapeutic approaches.
Details
- Title
- Anti-retroviral effects of type I IFN subtypes in vivo
- Authors/Creators
- N. Gerlach (Author/Creator) - University of Duisburg-EssenK. Gibbert (Author/Creator) - University of Duisburg-EssenC. Alter (Author/Creator) - University of Duisburg-EssenS. Nair (Author/Creator) - University of Duisburg-EssenG. Zelinskyy (Author/Creator) - University of Duisburg-EssenC.M. James (Author/Creator) - Murdoch UniversityU. Dittmer (Author/Creator) - University of Duisburg-Essen
- Publication Details
- European Journal of Immunology, Vol.39(1), pp.136-146
- Publisher
- John Wiley & Sons Ltd.
- Identifiers
- 991005543445707891
- Copyright
- © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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