Anti-virulence therapeutic approaches for Neisseria gonorrhoeae

K.Y.L. Lim; C.A. Mullally; E.C. Haese; E.A. Kibble; N.R. McCluskey; E.C. Mikucki; V.C. Thai; K.A. Stubbs; M. Sarkar-Tyson; C.M. Kahler

doi:10.3390/antibiotics10020103

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Anti-virulence therapeutic approaches for Neisseria gonorrhoeae

Journal article

Open access

Peer reviewed

Anti-virulence therapeutic approaches for Neisseria gonorrhoeae

K.Y.L. Lim, C.A. Mullally, E.C. Haese, E.A. Kibble, N.R. McCluskey, E.C. Mikucki, V.C. Thai, K.A. Stubbs, M. Sarkar-Tyson and C.M. Kahler

Antibiotics, Vol.10(2), Article 103

2021

DOI: https://doi.org/10.3390/antibiotics10020103

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Abstract

While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria meningitidis, the former has become resistant to commonly available over-the-counter antibiotic treatments. It is imperative then to develop new therapies that combat current AMR isolates whilst also circumventing the pathways leading to the development of AMR. This review highlights the growing research interest in developing anti-virulence therapies (AVTs) which are directed towards inhibiting virulence factors to prevent infection. By targeting virulence factors that are not essential for gonococcal survival, it is hypothesized that this will impart a smaller selective pressure for the emergence of resistance in the pathogen and in the microbiome, thus avoiding AMR development to the anti-infective. This review summates the current basis of numerous anti-virulence strategies being explored for N. gonorrhoeae.

Details

Title: Anti-virulence therapeutic approaches for Neisseria gonorrhoeae
Authors/Creators: K.Y.L. Lim (Author/Creator) - The University of Western Australia
C.A. Mullally (Author/Creator) - The University of Western Australia
E.C. Haese (Author/Creator) - The University of Western Australia
E.A. Kibble (Author/Creator) - The University of Western Australia
N.R. McCluskey (Author/Creator) - The University of Western Australia
E.C. Mikucki (Author/Creator) - The University of Western Australia
V.C. Thai (Author/Creator) - The University of Western Australia
K.A. Stubbs (Author/Creator) - The University of Western Australia
M. Sarkar-Tyson (Author/Creator) - The University of Western Australia
C.M. Kahler (Author/Creator) - The University of Western Australia
Publication Details: Antibiotics, Vol.10(2), Article 103
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Identifiers: 991005545552307891
Copyright: © 2021 by the authors
Murdoch Affiliation: School of Veterinary and Life Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.714 Neisseria/Haemophilus
Web Of Science research areas: Infectious Diseases; Pharmacology & Pharmacy
ESI research areas: Pharmacology & Toxicology