Journal article
Antibiotic allergy in pediatrics
Pediatrics, Vol.141(5)
2018
Abstract
The overlabeling of pediatric antibiotic allergy represents a huge burden in society. Given that up to 10% of the US population is labeled as penicillin allergic, it can be estimated that at least 5 million children in this country are labeled with penicillin allergy. We now understand that most of the cutaneous symptoms that are interpreted as drug allergy are likely viral induced or due to a drug–virus interaction, and they usually do not represent a long-lasting, drug-specific, adaptive immune response to the antibiotic that a child received. Because most antibiotic allergy labels acquired in childhood are carried into adulthood, the overlabeling of antibiotic allergy is a liability that leads to unnecessary long-term health care risks, costs, and antibiotic resistance. Fortunately, awareness of this growing burden is increasing and leading to more emphasis on antibiotic allergy delabeling strategies in the adult population. There is growing literature that is used to support the safe and efficacious use of tools such as skin testing and drug challenge to evaluate and manage children with antibiotic allergy labels. In addition, there is an increasing understanding of antibiotic reactivity within classes and side-chain reactions. In summary, a better overall understanding of the current tools available for the diagnosis and management of adverse drug reactions is likely to change how pediatric primary care providers evaluate and treat patients with such diagnoses and prevent the unnecessary avoidance of antibiotics, particularly penicillins.
Details
- Title
- Antibiotic allergy in pediatrics
- Authors/Creators
- A.E. Norton (Author/Creator) - Monroe Carell Jr. Children's HospitalK. Konvinse (Author/Creator) - Vanderbilt University Medical CenterE.J. Phillips (Author/Creator) - Monroe Carell Jr. Children's HospitalA.D. Broyles (Author/Creator) - Boston Children's Hospital
- Publication Details
- Pediatrics, Vol.141(5)
- Publisher
- American academy of Pediatrics
- Identifiers
- 991005543971507891
- Copyright
- © 2018 by the American Academy of Pediatrics
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Pediatrics
- ESI research areas
- Clinical Medicine