Antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

M. Macedo-Viñas; J. Conly; P. Francois; R. Aschbacher; D.S. Blanc; G. Coombs; G. Daikos; B. Dhawan; J. Empel; J. Etienne; A.M.S. Figueiredo; G. Golding; L. Han; H.B. Kim; R. Köck; A. Larsen; F. Layer; J. Lo; T. Maeda; M. Mulvey; A. Pantosti; T. Saga; J. Schrenzel; A. Simor; R. Skov; M. Van Rijen; H. Wang; Z. Zakaria; S. Harbarth

doi:10.1016/j.jgar.2013.08.003

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Antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

Journal article

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Antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

M. Macedo-Viñas, J. Conly, P. Francois, R. Aschbacher, D.S. Blanc, G. Coombs, G. Daikos, B. Dhawan, J. Empel, J. Etienne, …

Journal of Global Antimicrobial Resistance, Vol.2(1), pp.43-47

2014

DOI: https://doi.org/10.1016/j.jgar.2013.08.003

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Abstract

The antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) isolates reported from 17 countries in the Americas, Europe and, Australia-Asia were analysed. Among a total of 3236 non-duplicate isolates, the lowest susceptibility was observed to erythromycin in all regions. Susceptibility to ciprofloxacin showed large variation (25%, 75% and 84% in the Americas, Europe and Australia-Asia, respectively). Two vancomycin-intermediate PVL-positive MRSA isolates were reported, one from Hong Kong and the other from The Netherlands. Resistance to trimethoprim/sulfamethoxazole and linezolid was <1%. Among 1798 MRSA isolates from 13 countries that were tested for the requested 10 non-β-lactam antibiotics, 49.4% were multisusceptible. However, multiresistant isolates (resistant to at least three classes of non-β-lactam antibiotics) were reported from all regions. Sequence type 30 (ST30) was reported worldwide, whereas ST80 and ST93 were exclusive to Europe and Australia, respectively. USA300 and related clones (ST8) are progressively replacing the ST80 clone in several European countries. Eight major clusters were discriminated by multilocus variable-number tandem repeat assay (MLVA), showing a certain geographic specificity. PVL-positive MRSA isolates frequently remain multisusceptible to non-β-lactam agents, but multiresistance is already prevalent in all regions. Surveillance of MRSA susceptibility patterns should be monitored to provide clinicians with the most current information regarding changes in resistance patterns.

Details

Title: Antibiotic susceptibility and molecular epidemiology of Panton–Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey
Authors/Creators: M. Macedo-Viñas (Author/Creator) - University of Geneva
J. Conly (Author/Creator) - University of Calgary
P. Francois (Author/Creator) - University of Geneva
R. Aschbacher (Author/Creator) - Laboratorio Aziendale de Microbiologia e Virologia, Bolzano, Italy
D.S. Blanc (Author/Creator) - University Hospital of Lausanne
G. Coombs (Author/Creator) - Curtin University
G. Daikos (Author/Creator) - Laiko General Hospital of Athens
B. Dhawan (Author/Creator) - All India Institute of Medical Sciences
J. Empel (Author/Creator) - National Academy of Medicine
J. Etienne (Author/Creator) - National Reference Center for Staphylococci, Lyon, France
A.M.S. Figueiredo (Author/Creator) - Universidade Federal do Rio de Janeiro
G. Golding (Author/Creator)
L. Han (Author/Creator) - Ruijin Hospital
H.B. Kim (Author/Creator)
R. Köck (Author/Creator) - University Hospital Münster
A. Larsen (Author/Creator) - Statens Serum Institut
F. Layer (Author/Creator) - Robert Koch Institute
J. Lo (Author/Creator) - Department of Health
T. Maeda (Author/Creator) - Toho University Omori Medical Center
M. Mulvey (Author/Creator) - National Microbiology Laboratory
A. Pantosti (Author/Creator) - Istituto Superiore di Sanità
T. Saga (Author/Creator) - Toho University Omori Medical Center
J. Schrenzel (Author/Creator) - University of Geneva
A. Simor (Author/Creator) - Sunnybrook Health Science Centre
R. Skov (Author/Creator) - Statens Serum Institut
M. Van Rijen (Author/Creator) - Laboratory for Microbiology and Infection Control, Breda, The Netherlands
H. Wang (Author/Creator) - Peking Union Medical College Hospital
Z. Zakaria (Author/Creator) - Universiti Putra Malaysia
S. Harbarth (Author/Creator) - University of Geneva
Publication Details: Journal of Global Antimicrobial Resistance, Vol.2(1), pp.43-47
Publisher: Elsevier BV
Identifiers: 991005541438007891
Copyright: © 2013 International Society for Chemotherapy of Infection and Cancer.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 MRSA and VRE
Web Of Science research areas: Infectious Diseases; Pharmacology & Pharmacy
ESI research areas: Immunology