Journal article
Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection
AIDS, Vol.25(11), pp.1379-1383
2011
Abstract
Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection.
Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n = 23) and ART-treated (n = 27) HIV patients.
Methods: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma.
Results: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P = 0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P < 0.0001) and levels of IgG anti-LPS correlated with IgM+ memory B-cell counts (P = 0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4+ T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA.
Conclusion: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients.
Details
- Title
- Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection
- Authors/Creators
- A. Lim (Author/Creator) - The University of Western AustraliaA. Amini (Author/Creator) - School of Pathology and Laboratory MedicineL.J. D’Orsogna (Author/Creator)R. Rajasuriar (Author/Creator) - National University of SingaporeM. Kramski (Author/Creator) - The University of MelbourneS.R. Lewin (Author/Creator) - The Alfred HospitalD.F. Purcell (Author/Creator) - The University of MelbourneP. Price (Author/Creator) - School of Pathology and Laboratory MedicineM.A. French (Author/Creator) - School of Pathology and Laboratory Medicine
- Publication Details
- AIDS, Vol.25(11), pp.1379-1383
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005543356907891
- Copyright
- © 2017 Wolters Kluwer Health, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
22 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.66 HIV
- 1.66.46 HIV Pathogenesis
- Web Of Science research areas
- Immunology
- Infectious Diseases
- Virology
- ESI research areas
- Immunology