Journal article
Antifungal hypersensitivity reactions and cross-reactivity patterns
Current Opinion in Infectious Diseases, Vol.34(6), pp.559-572
2021
Abstract
Purpose of review
The goal of this article is to provide an updated understanding and evidence-based approach where possible for antifungal hypersensitivity. This includes recognition of clinical phenotype, implications for cross-reactivity and diagnostic, and management strategy for immediate and delayed hypersensitivity reactions.
Recent findings
Antifungal hypersensitivity reactions can be classified according to their latency (immediate or delayed) and clinical phenotype. The majority of the cases described in the literature are delayed T-cell mediated reactions of various severities but immediate reactions consistent with non-Immunoglobulin E (IgE)-mediated mast cell activation and IgE-mediated reactions have also been described. Ancillary information such as skin testing, drug challenge and ex vivo experimental approaches can aid causality assessments and inform antifungal class cross-reactivity, which help optimize antifungal prescribing and stewardship.
Summary
This review will update the clinician on mechanisms of drug hypersensitivity as well as providing a structured approach to the recognition, diagnosis and management of antifungal hypersensitivity reaction.
Details
- Title
- Antifungal hypersensitivity reactions and cross-reactivity patterns
- Authors/Creators
- A.M. Copaescu (Author/Creator) - McGill University Health CentreE.J. Phillips (Author/Creator) - Murdoch UniversityJ.A. Trubiano (Author/Creator) - Austin Health
- Publication Details
- Current Opinion in Infectious Diseases, Vol.34(6), pp.559-572
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Identifiers
- 991005542992707891
- Copyright
- © 2021 Wolters Kluwer Health
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.265 Dermatology - Skin Allergies
- 1.265.1140 Drug Hypersensitivity
- Web Of Science research areas
- Infectious Diseases
- ESI research areas
- Immunology