Antimicrobial Resistance of and Genomic Insights into Pasteurella multocida Strains Isolated from Australian Pigs

Alec Truswell; Tanya J Laird; Suzanna Jones; Mark O'Dea; John Blinco; Rebecca Abraham; Daniel Morison; David Jordan; David J Hampson; Stanley Pang; Sam Abraham

doi:10.1128/spectrum.03784-22

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Antimicrobial Resistance of and Genomic Insights into Pasteurella multocida Strains Isolated from Australian Pigs

Journal article

Open access

Peer reviewed

Antimicrobial Resistance of and Genomic Insights into Pasteurella multocida Strains Isolated from Australian Pigs

Alec Truswell, Tanya J Laird, Suzanna Jones, Mark O'Dea, John Blinco, Rebecca Abraham, Daniel Morison, David Jordan, David J Hampson, Stanley Pang, …

Microbiology spectrum, Vol.11(1), e0378422

2023

DOI: https://doi.org/10.1128/spectrum.03784-22

PMID: 36651773

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Abstract

Pasteurella multocida

pigs

Australia

antimicrobial resistance

genomic comparisons

Infection with Pasteurella multocida represents a significant economic threat to Australian pig producers, yet our knowledge of its antimicrobial susceptibilities is lagging, and genomic characterization of P. multocida strains associated with porcine lower respiratory disease is internationally scarce. This study utilized high-throughput robotics to phenotypically and genetically characterize an industry-wide collection of 252 clinical P. multocida isolates that were recovered between 2014 and 2019. Overall, antimicrobial resistance was found to be low, with clinical resistance below 1% for all tested antimicrobials except those from the tetracycline class. Five dominant sequence types, representing 64.8% of all isolates, were identified; they were disseminated across farms and had previously been detected in various animal hosts and countries. P. multocida in Australian farms remain controllable via current antimicrobial therapeutic protocols. The identification of highly dominant, interspecies-infecting strains provides insight into the epidemiology of the opportunistic pathogen, and it highlights a biosecurity threat to the Australian livestock industry.

Details

Title: Antimicrobial Resistance of and Genomic Insights into Pasteurella multocida Strains Isolated from Australian Pigs
Authors/Creators: Alec Truswell - Murdoch University
Tanya J Laird - Murdoch University
Suzanna Jones - Murdoch University
Mark O'Dea - Murdoch University
John Blinco - Murdoch University
Rebecca Abraham - Murdoch University
Daniel Morison - ACE Laboratory Services, Bendigo, Victoria, Australia
David Jordan - New South Wales Department of Primary Industries
David J Hampson - Murdoch University
Stanley Pang - Murdoch University
Sam Abraham - Murdoch University
Publication Details: Microbiology spectrum, Vol.11(1), e0378422
Identifiers: 991005579458107891
Copyright: © 2023 Truswell et al
Murdoch Affiliation: Antimicrobial Resistance and Infectious Disease Laboratory; Centre for Biosecurity and One Health; School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.248 Sexually Transmitted Infections; 1.248.1656 Pasteurella Multocida
Web Of Science research areas: Microbiology
ESI research areas: Microbiology