Antimicrobial prophylaxis in companion animal surgery: a scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines

T.M. Sørensen; K Scahill; Jorge Espinel Ruperez; M. Olejnik; F Swinbourne; D.R. Verwilghen; M.C. Nolff; S.J. Baines; C Marques; A Vilen; E L Duarte; M Dias; S Dewulf; A. Wichtowska; A. Carranza Valencia; L Pelligand; E M Broens; Pierre-Louis Toutain; M Alishani; J.S. Weese; M L Brennan; L R Jessen; F Allerton

doi:10.1016/j.tvjl.2024.106101

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Antimicrobial prophylaxis in companion animal surgery: a scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines

Journal article

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Antimicrobial prophylaxis in companion animal surgery: a scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines

T.M. Sørensen, K Scahill, Jorge Espinel Ruperez, M. Olejnik, F Swinbourne, D.R. Verwilghen, M.C. Nolff, S.J. Baines, C Marques, A Vilen, …

The veterinary journal (1997), 106101

2024

DOI: https://doi.org/10.1016/j.tvjl.2024.106101

PMID: 38490359

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Abstract

Surgical Site Infection

Cats

SAP

Dogs

SSI

Antimicrobial stewardship

Peri-operative

Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is. Therefore, it is difficult for surgeons to properly weigh the costs, risks and benefits for individual patients when deciding on the use of SAP, making it challenging to promote antimicrobial stewardship in primary practice settings. The objective of this study was to map the veterinary evidence focused on assessing the effect of SAPon SSI development and in order to identify surgical procedures with some research evidence and possible knowledge gaps. In October 2021 and December 2022, Scopus, CAB Abstracts, Web of Science Core Collection, Embase and MEDLINE were systematically searched. Double blinded screening of records was performed to identify studies in companion animals that reported on the use of SAP and SSI rates. Comparative data were available from 34 out of 39,123 records screened including: eight randomised controlled trials (RCT), 23 cohort studies (seven prospective and 16 retrospective) and three retrospective case series representing 12,872 dogs and cats in total. Extracted data described peri- or post-operative SAP in nine, and 25 studies, respectively. In the eight RCTs evaluating SAP in companion animals, surgical procedure coverage wasskewed towards orthopaedic stifle surgeries in referral settings and there was large variation in SAP protocols, SSI definitions and follow-up intervals. More standardized data collection and agreement of SSI definitions is needed to build stronger evidence for optimized patient care.

Details

Title: Antimicrobial prophylaxis in companion animal surgery: a scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines
Authors/Creators: T.M. Sørensen
K Scahill
Jorge Espinel Ruperez (Author)
M. Olejnik - Department of Fundamental and Preclinical Sciences, Nicolaus Copernicus University, Jurija Gagarina 11, 87-100 Toruń, Poland
F Swinbourne - Lumbry Park Veterinary Specialists, Selborne Rd, Alton GU34 3HL, United Kingdom
D.R. Verwilghen - Sydney School of Veterinary Science, University of Sydney, Regimental Dr, Camperdown NSW 2050, Australia
M.C. Nolff - Clinic for Small Animal Surgery, Vetsuisse Faculty, University Zürich, Winterthurerstrasse 260, TFA 01.51, 8057 Zürich, Switzerland
S.J. Baines - Willows Veterinary Centre & Referral Service, Solihull B90 4NH, United Kingdom
C Marques
A Vilen - AniCura Landskrona Smådjursklinik, Föreningsgatan 165, 261 51 Landskrona, Sweden
E L Duarte
M Dias - Mediterranean Institute for Agriculture, Environment and Development & Departamento de Medicina Veterinária, Escola de Ciências e Tecnologia, Universidade de Évora, Universidade de Évora, Pólo da Mitra Apartado 94, 7006-554 Évora, Portugal
S Dewulf - Veterinary Epidemiology Unit, Faculty of Veterinary Medicine, Ghent University, Gebouw D4, Salisburylaan 133, 9820 Merelbeke, Ghent, Belgium
A. Wichtowska - Department of Fundamental and Preclinical Sciences, Nicolaus Copernicus University, Jurija Gagarina 11, 87-100 Toruń, Poland
A. Carranza Valencia - Department of Clinical Veterinary Medicine, Vetsuisse Faculty, Bern University, Länggassstrasse 120, 3012 Bern, Switzerland
L Pelligand
E M Broens
Pierre-Louis Toutain
M Alishani - Department of Veterinary Medicine, Faculty of Agriculture and Veterinary, University of Prishtina "Hasan Prishtina", 10 000, Prishtina, Kosovo
J.S. Weese - Dept of Pathobiology, Ontario Veterinary College, University of Guelph, 419 Gordon St, Guelph, ON N1G 2W1, Canada
M L Brennan - Centre for Evidence-based Veterinary Medicine, The University of Nottingham, Loughborough LE12 5RD, United Kingdom
L R Jessen
F Allerton - Willows Veterinary Centre & Referral Service, Solihull B90 4NH, United Kingdom
Publication Details: The veterinary journal (1997), 106101
Publisher: Elsevier Ltd.
Identifiers: 991005648670307891
Murdoch Affiliation: School of Veterinary Medicine
Language: English
Resource Type: Journal article

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