Journal article
Antimicrobial resistance in Clostridioides difficile
European Journal of Clinical Microbiology & Infectious Diseases
2021
Abstract
Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.
Details
- Title
- Antimicrobial resistance in Clostridioides difficile
- Authors/Creators
- K. O'Grady (Author/Creator)D.R. Knight (Author/Creator) - Murdoch UniversityT.V. Riley (Author/Creator) - Murdoch University
- Publication Details
- European Journal of Clinical Microbiology & Infectious Diseases
- Publisher
- Springer Verlag
- Identifiers
- 991005540743807891
- Murdoch Affiliation
- Harry Butler Institute; Centre for Biosecurity and One Health
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.120 Inflammatory Bowel Diseases & Infections
- 1.120.1133 Clostridium Infections
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- ESI research areas
- Microbiology