Antimicrobial resistance in Staphylococcus aureus and Enterococci spp. isolates from bloodstream infections in Australian children, 2013 - 2021

Anita Williams; Geoffrey W Coombs; Jan M Bell; Denise A Daley; Shakeel Mowlaboccus; Penelope Bryant; Anita Campbell; Louise Cooley; Jon Iredell; Adam D Irwin; Alison Kesson; Brendan McMullan; Morgyn S Warner; Phoebe Williams; Christopher C Blyth

doi:10.1093/jpids/piae110

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Antimicrobial resistance in Staphylococcus aureus and Enterococci spp. isolates from bloodstream infections in Australian children, 2013 - 2021

Journal article

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Antimicrobial resistance in Staphylococcus aureus and Enterococci spp. isolates from bloodstream infections in Australian children, 2013 - 2021

Anita Williams, Geoffrey W Coombs, Jan M Bell, Denise A Daley, Shakeel Mowlaboccus, Penelope Bryant, Anita Campbell, Louise Cooley, Jon Iredell, Adam D Irwin, …

Journal of the Pediatric Infectious Diseases Society, piae110

2024

DOI: https://doi.org/10.1093/jpids/piae110

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Abstract

Background Rising proportions of antimicrobial resistance (AMR) have been observed in both Staphylococcus aureus and Enterococcus spp. isolates. Methods The Australian Group on Antimicrobial Resistance (AGAR) surveillance program captures clinical and microbiological data of isolates detected in blood cultures across Australia. EUCAST 2022 was used for MIC interpretation and the AMR package in R for data analysis. Results There were 2,091 BSIs with S. aureus and 534 enterococcal BSI episodes over the nine years. Three-quarters of S. aureus BSI episodes were community-onset (78.3%) whilst more than half of enterococcal BSIs were hospital-onset (56.9%). The median age for S. aureus BSIs was 6 years, whilst >50% enterococcal BSIs were in children <12 months old. Fifteen percent of S. aureus isolates were methicillin-resistant (MRSA). Overall, 85.3% of S. aureus were resistant to penicillin, 12.5% resistant to erythromycin, 10.3% to clindamycin, and 4.7% to ciprofloxacin. Resistance to penicillin decreased over time whilst clindamycin resistance increased. Resistance in Enterococcus spp. was almost entirely observed in E. faecium; only one E. faecalis isolate was ampicillin resistant, and no E. faecalis isolates were vancomycin or teicoplanin resistant. Seventy-three percent of E. faecium were resistant to ampicillin, 25.5% to vancomycin (VREfm) and 8.8% to teicoplanin. Conclusion Significant shifts in the epidemiology and resistance profiles of S. aureus and Enterococcus spp. BSIs in Australian children were observed, making clear the importance of age-stratified reporting in antimicrobial resistance data.

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Title: Antimicrobial resistance in Staphylococcus aureus and Enterococci spp. isolates from bloodstream infections in Australian children, 2013 - 2021
Authors/Creators: Anita Williams
Geoffrey W Coombs
Jan M Bell
Denise A Daley
Shakeel Mowlaboccus
Penelope Bryant - Royal Children's Hospital
Anita Campbell - The University of Western Australia
Louise Cooley - Royal Hobart Hospital
Jon Iredell
Adam D Irwin - The University of Queensland
Alison Kesson - Children's Hospital at Westmead
Brendan McMullan - UNSW Sydney
Morgyn S Warner - South Australia Pathology
Phoebe Williams - UNSW Sydney
Christopher C Blyth - The University of Western Australia
Publication Details: Journal of the Pediatric Infectious Diseases Society, piae110
Publisher: Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.
Identifiers: 991005708507107891
Murdoch Affiliation: Centre for Biosecurity and One Health; School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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